Interindividual variability in response to continuous theta-burst stimulation in healthy adults
•Cluster analysis can identify subpopulations in healthy adults with distinct cTBS responses.•MEP changes at 10 and 40min post-cTBS best predicted the results of the cluster analysis.•Variability in cTBS response after 10min was influenced by BDNF polymorphism and cTBS intensity. We used complete-li...
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| Veröffentlicht in: | Clinical neurophysiology 2017-11, Vol.128 (11), p.2268-2278 |
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| creator | Jannati, Ali Block, Gabrielle Oberman, Lindsay M. Rotenberg, Alexander Pascual-Leone, Alvaro |
| description | •Cluster analysis can identify subpopulations in healthy adults with distinct cTBS responses.•MEP changes at 10 and 40min post-cTBS best predicted the results of the cluster analysis.•Variability in cTBS response after 10min was influenced by BDNF polymorphism and cTBS intensity.
We used complete-linkage cluster analysis to identify healthy subpopulations with distinct responses to continuous theta-burst stimulation (cTBS).
21 healthy adults (age±SD, 36.9±15.2years) underwent cTBS of left motor cortex. Natural log-transformed motor evoked potentials (LnMEPs) at 5–50min post-cTBS (T5–T50) were calculated.
Two clusters were found; Group 1 (n=12) that showed significant MEP facilitation at T15, T20, and T50 (p’s |
| doi_str_mv | 10.1016/j.clinph.2017.08.023 |
| format | Article |
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We used complete-linkage cluster analysis to identify healthy subpopulations with distinct responses to continuous theta-burst stimulation (cTBS).
21 healthy adults (age±SD, 36.9±15.2years) underwent cTBS of left motor cortex. Natural log-transformed motor evoked potentials (LnMEPs) at 5–50min post-cTBS (T5–T50) were calculated.
Two clusters were found; Group 1 (n=12) that showed significant MEP facilitation at T15, T20, and T50 (p’s<0.006), and Group 2 (n=9) that showed significant suppression at T5–T15 (p’s<0.022). LnMEPs at T10 and T40 were best predictors of, and together accounted for 80% of, cluster assignment.
In an exploratory analysis, we examined the roles of brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) polymorphisms in the cTBS response. Val66Met participants showed greater facilitation at T10 than Val66Val participants (p=0.025). BDNF and cTBS intensity predicted 59% of interindividual variability in LnMEP at T10. APOE did not significantly affect LnMEPs at any time point (p’s>0.32).
Data-driven cluster analysis can identify healthy subpopulations with distinct cTBS responses. T10 and T40 LnMEPs were best predictors of cluster assignment. T10 LnMEP was influenced by BDNF polymorphism and cTBS intensity.
Healthy adults can be sorted into subpopulations with distinct cTBS responses that are influenced by genetics.</description><identifier>ISSN: 1388-2457</identifier><identifier>EISSN: 1872-8952</identifier><identifier>DOI: 10.1016/j.clinph.2017.08.023</identifier><identifier>PMID: 29028501</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Apolipoproteins E - genetics ; BDNF ; Brain-Derived Neurotrophic Factor - genetics ; Cluster analysis ; Continuous theta-burst stimulation ; Evoked Potentials, Motor - physiology ; Female ; Healthy Volunteers ; Humans ; Individuality ; Interindividual variability ; Male ; Middle Aged ; Motor Cortex - physiology ; Neuronal Plasticity - physiology ; Plasticity ; Transcranial Magnetic Stimulation ; Young Adult</subject><ispartof>Clinical neurophysiology, 2017-11, Vol.128 (11), p.2268-2278</ispartof><rights>2017 International Federation of Clinical Neurophysiology</rights><rights>Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-49c2d0fba873b24e3992084f0e037ad5e7b3e80f66c9e5dd7ec5153357b532833</citedby><cites>FETCH-LOGICAL-c463t-49c2d0fba873b24e3992084f0e037ad5e7b3e80f66c9e5dd7ec5153357b532833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinph.2017.08.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29028501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jannati, Ali</creatorcontrib><creatorcontrib>Block, Gabrielle</creatorcontrib><creatorcontrib>Oberman, Lindsay M.</creatorcontrib><creatorcontrib>Rotenberg, Alexander</creatorcontrib><creatorcontrib>Pascual-Leone, Alvaro</creatorcontrib><title>Interindividual variability in response to continuous theta-burst stimulation in healthy adults</title><title>Clinical neurophysiology</title><addtitle>Clin Neurophysiol</addtitle><description>•Cluster analysis can identify subpopulations in healthy adults with distinct cTBS responses.•MEP changes at 10 and 40min post-cTBS best predicted the results of the cluster analysis.•Variability in cTBS response after 10min was influenced by BDNF polymorphism and cTBS intensity.
We used complete-linkage cluster analysis to identify healthy subpopulations with distinct responses to continuous theta-burst stimulation (cTBS).
21 healthy adults (age±SD, 36.9±15.2years) underwent cTBS of left motor cortex. Natural log-transformed motor evoked potentials (LnMEPs) at 5–50min post-cTBS (T5–T50) were calculated.
Two clusters were found; Group 1 (n=12) that showed significant MEP facilitation at T15, T20, and T50 (p’s<0.006), and Group 2 (n=9) that showed significant suppression at T5–T15 (p’s<0.022). LnMEPs at T10 and T40 were best predictors of, and together accounted for 80% of, cluster assignment.
In an exploratory analysis, we examined the roles of brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) polymorphisms in the cTBS response. Val66Met participants showed greater facilitation at T10 than Val66Val participants (p=0.025). BDNF and cTBS intensity predicted 59% of interindividual variability in LnMEP at T10. APOE did not significantly affect LnMEPs at any time point (p’s>0.32).
Data-driven cluster analysis can identify healthy subpopulations with distinct cTBS responses. T10 and T40 LnMEPs were best predictors of cluster assignment. T10 LnMEP was influenced by BDNF polymorphism and cTBS intensity.
Healthy adults can be sorted into subpopulations with distinct cTBS responses that are influenced by genetics.</description><subject>Adult</subject><subject>Aged</subject><subject>Apolipoproteins E - genetics</subject><subject>BDNF</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cluster analysis</subject><subject>Continuous theta-burst stimulation</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Individuality</subject><subject>Interindividual variability</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Cortex - physiology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Plasticity</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Young Adult</subject><issn>1388-2457</issn><issn>1872-8952</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo7rr6D0T66KXbStLppC-CLH4sLHjRc0gn1XaGTDIm6YH59_Yw66oXT1VQ9b718RDymkJHgQ7vdp0NPh6WjgGVHagOGH9CrqmSrFWjYE-3nCvVsl7IK_KilB0ASOjZc3LFRmBKAL0m-i5WzD46f_RuNaE5muzN5IOvp8bHJmM5pFiwqamxKVYf17SWpi5YTTutudSmVL9fg6k-xbNiQRPqcmqMW0MtL8mz2YSCrx7iDfn-6eO32y_t_dfPd7cf7lvbD7y2_WiZg3kySvKJ9cjHkYHqZ0Dg0jiBcuKoYB4GO6JwTqIVVHAu5CQ4U5zfkPcX38M67dFZjDWboA_Z700-6WS8_rcS_aJ_pKMWgxQK5Gbw9sEgp58rlqr3vlgMwUTcLtZ0FLSnEijbWvtLq82plIzz4xgK-sxG7_SFjT6z0aD0xmaTvfl7xUfRbxh_bsDtUUePWRfrMVp0PqOt2iX__wm_ALDlpU8</recordid><startdate>20171101</startdate><enddate>20171101</enddate><creator>Jannati, Ali</creator><creator>Block, Gabrielle</creator><creator>Oberman, Lindsay M.</creator><creator>Rotenberg, Alexander</creator><creator>Pascual-Leone, Alvaro</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20171101</creationdate><title>Interindividual variability in response to continuous theta-burst stimulation in healthy adults</title><author>Jannati, Ali ; Block, Gabrielle ; Oberman, Lindsay M. ; Rotenberg, Alexander ; Pascual-Leone, Alvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-49c2d0fba873b24e3992084f0e037ad5e7b3e80f66c9e5dd7ec5153357b532833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Apolipoproteins E - genetics</topic><topic>BDNF</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Cluster analysis</topic><topic>Continuous theta-burst stimulation</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Individuality</topic><topic>Interindividual variability</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Cortex - physiology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Plasticity</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jannati, Ali</creatorcontrib><creatorcontrib>Block, Gabrielle</creatorcontrib><creatorcontrib>Oberman, Lindsay M.</creatorcontrib><creatorcontrib>Rotenberg, Alexander</creatorcontrib><creatorcontrib>Pascual-Leone, Alvaro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jannati, Ali</au><au>Block, Gabrielle</au><au>Oberman, Lindsay M.</au><au>Rotenberg, Alexander</au><au>Pascual-Leone, Alvaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interindividual variability in response to continuous theta-burst stimulation in healthy adults</atitle><jtitle>Clinical neurophysiology</jtitle><addtitle>Clin Neurophysiol</addtitle><date>2017-11-01</date><risdate>2017</risdate><volume>128</volume><issue>11</issue><spage>2268</spage><epage>2278</epage><pages>2268-2278</pages><issn>1388-2457</issn><eissn>1872-8952</eissn><abstract>•Cluster analysis can identify subpopulations in healthy adults with distinct cTBS responses.•MEP changes at 10 and 40min post-cTBS best predicted the results of the cluster analysis.•Variability in cTBS response after 10min was influenced by BDNF polymorphism and cTBS intensity.
We used complete-linkage cluster analysis to identify healthy subpopulations with distinct responses to continuous theta-burst stimulation (cTBS).
21 healthy adults (age±SD, 36.9±15.2years) underwent cTBS of left motor cortex. Natural log-transformed motor evoked potentials (LnMEPs) at 5–50min post-cTBS (T5–T50) were calculated.
Two clusters were found; Group 1 (n=12) that showed significant MEP facilitation at T15, T20, and T50 (p’s<0.006), and Group 2 (n=9) that showed significant suppression at T5–T15 (p’s<0.022). LnMEPs at T10 and T40 were best predictors of, and together accounted for 80% of, cluster assignment.
In an exploratory analysis, we examined the roles of brain-derived neurotrophic factor (BDNF) and apolipoprotein E (APOE) polymorphisms in the cTBS response. Val66Met participants showed greater facilitation at T10 than Val66Val participants (p=0.025). BDNF and cTBS intensity predicted 59% of interindividual variability in LnMEP at T10. APOE did not significantly affect LnMEPs at any time point (p’s>0.32).
Data-driven cluster analysis can identify healthy subpopulations with distinct cTBS responses. T10 and T40 LnMEPs were best predictors of cluster assignment. T10 LnMEP was influenced by BDNF polymorphism and cTBS intensity.
Healthy adults can be sorted into subpopulations with distinct cTBS responses that are influenced by genetics.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>29028501</pmid><doi>10.1016/j.clinph.2017.08.023</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Apolipoproteins E - genetics BDNF Brain-Derived Neurotrophic Factor - genetics Cluster analysis Continuous theta-burst stimulation Evoked Potentials, Motor - physiology Female Healthy Volunteers Humans Individuality Interindividual variability Male Middle Aged Motor Cortex - physiology Neuronal Plasticity - physiology Plasticity Transcranial Magnetic Stimulation Young Adult |
| title | Interindividual variability in response to continuous theta-burst stimulation in healthy adults |
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