Interindividual variability in response to continuous theta-burst stimulation in healthy adults

•Cluster analysis can identify subpopulations in healthy adults with distinct cTBS responses.•MEP changes at 10 and 40min post-cTBS best predicted the results of the cluster analysis.•Variability in cTBS response after 10min was influenced by BDNF polymorphism and cTBS intensity. We used complete-li...

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Veröffentlicht in:	Clinical neurophysiology 2017-11, Vol.128 (11), p.2268-2278
Hauptverfasser:	Jannati, Ali, Block, Gabrielle, Oberman, Lindsay M., Rotenberg, Alexander, Pascual-Leone, Alvaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Apolipoproteins E - genetics BDNF Brain-Derived Neurotrophic Factor - genetics Cluster analysis Continuous theta-burst stimulation Evoked Potentials, Motor - physiology Female Healthy Volunteers Humans Individuality Interindividual variability Male Middle Aged Motor Cortex - physiology Neuronal Plasticity - physiology Plasticity Transcranial Magnetic Stimulation Young Adult
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Zusammenfassung:	•Cluster analysis can identify subpopulations in healthy adults with distinct cTBS responses.•MEP changes at 10 and 40min post-cTBS best predicted the results of the cluster analysis.•Variability in cTBS response after 10min was influenced by BDNF polymorphism and cTBS intensity. We used complete-linkage cluster analysis to identify healthy subpopulations with distinct responses to continuous theta-burst stimulation (cTBS). 21 healthy adults (age±SD, 36.9±15.2years) underwent cTBS of left motor cortex. Natural log-transformed motor evoked potentials (LnMEPs) at 5–50min post-cTBS (T5–T50) were calculated. Two clusters were found; Group 1 (n=12) that showed significant MEP facilitation at T15, T20, and T50 (p’s
ISSN:	1388-2457 1872-8952
DOI:	10.1016/j.clinph.2017.08.023