Plasma interleukin-27 levels in patients with coronary artery disease

Interleukin (IL)-27, one of cytokines in the IL-12 family, is considered to have both pro- and anti-inflammatory properties. However, blood IL-27 levels in coronary artery disease (CAD) have not been fully elucidated yet. This cross-sectional study was done to elucidate the association between blood...

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Veröffentlicht in:	Medicine (Baltimore) 2017-10, Vol.96 (43), p.e8260-e8260
Hauptverfasser:	Miura, Kotaro, Saita, Emi, Suzuki-Sugihara, Norie, Miyata, Koutaro, Ikemura, Nobuhiro, Ohmori, Reiko, Ikegami, Yukinori, Kishimoto, Yoshimi, Kondo, Kazuo, Momiyama, Yukihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Coronary Syndrome - blood Acute Coronary Syndrome - complications Acute Coronary Syndrome - diagnostic imaging Aged Biomarkers - blood C-Reactive Protein - metabolism Coronary Angiography Coronary Artery Disease - blood Coronary Artery Disease - complications Coronary Artery Disease - diagnostic imaging Cross-Sectional Studies Diabetes Complications Disease Progression Female Humans Hypertension - complications Inflammation - blood Interleukin-27 - blood Male Middle Aged Observational Study Severity of Illness Index
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Zusammenfassung:	Interleukin (IL)-27, one of cytokines in the IL-12 family, is considered to have both pro- and anti-inflammatory properties. However, blood IL-27 levels in coronary artery disease (CAD) have not been fully elucidated yet. This cross-sectional study was done to elucidate the association between blood IL-27 levels and CAD.We investigated plasma IL-27 and high-sensitivity C-reactive protein (hsCRP) levels in 274 consecutive patients who underwent elective coronary angiography for suspected CAD. CAD was present in 177 patients [30 acute coronary syndrome (ACS) and 147 stable CAD]. Compared with 97 patients without CAD, 177 patients with CAD had higher IL-27 (median 0.26 vs 0.22 ng/mL, P
ISSN:	0025-7974 1536-5964
DOI:	10.1097/MD.0000000000008260