Human Group 2 innate lymphoid cells do not express the IL-5 receptor

Human Group 2 innate lymphoid cells do not express the IL-5 receptor

Capsule summary: Group 2 innate lymphoid cells (ILC2s) are upstream regulators of IL-5-dependent eosinophil function in asthma. We’ve shown that ILC2s do not express the IL-5R and thus IL-5R-dependent therapeutic interventions (e.g. Benralizumab) are unlikely to be mediated directly on ILC2s.

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Veröffentlicht in:Journal of allergy and clinical immunology 2017-11, Vol.140 (5), p.1430-1433.e4
Hauptverfasser: Wright, Adam K.A., PhD, Weston, Cathryn, PhD, Rana, Batika M.J., PhD, Brightling, Christopher E., PhD, FRCP, Cousins, David J., PhD
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Asthma
Blood
Cytokines
Inflammation
Interleukin 5
Leukocytes (eosinophilic)
Lymphocytes
Lymphoid cells
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Zusammenfassung:Capsule summary: Group 2 innate lymphoid cells (ILC2s) are upstream regulators of IL-5-dependent eosinophil function in asthma. We’ve shown that ILC2s do not express the IL-5R and thus IL-5R-dependent therapeutic interventions (e.g. Benralizumab) are unlikely to be mediated directly on ILC2s.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2017.04.025