Mannose-Binding Lectin Levels Could Predict Prognosis in IgA Nephropathy

IgA nephropathy (IgAN) is characterized by infections followed by episodic gross hematuria. Deficiency of mannose-binding lectin (MBL) is associated with recurrent infection in many diseases, but controversy exists regarding the role of MBL in IgAN. Here, we measured variants and MBL levels in 749 p...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2017-11, Vol.28 (11), p.3175-3181
Hauptverfasser:	Guo, Wei-Yi, Zhu, Li, Meng, Si-Jun, Shi, Su-Fang, Liu, Li-Jun, Lv, Ji-Cheng, Zhang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Brief Communications Female Glomerulonephritis, IGA - blood Glomerulonephritis, IGA - complications Humans Male Mannose-Binding Lectin - blood Mannose-Binding Lectin - deficiency Metabolism, Inborn Errors - etiology Prognosis Retrospective Studies
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Zusammenfassung:	IgA nephropathy (IgAN) is characterized by infections followed by episodic gross hematuria. Deficiency of mannose-binding lectin (MBL) is associated with recurrent infection in many diseases, but controversy exists regarding the role of MBL in IgAN. Here, we measured variants and MBL levels in 749 patients with IgAN and 489 healthy controls. Overall, 5.2% (39 of 749) of patients with IgAN had MBL deficiency (MBL levels
ISSN:	1046-6673 1533-3450
DOI:	10.1681/ASN.2017010076