Association Analysis of the MHC in Lupus Nephritis

Association Analysis of the MHC in Lupus Nephritis

Lupus nephritis (LN) is one of the most prevalent and serious complications of SLE, with significant effects on patient and renal survival. Although a large number of genetic variants associated with SLE have been identified, biomarkers that correlate with LN are extremely limited. In this study, we...

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Veröffentlicht in:Journal of the American Society of Nephrology 2017-11, Vol.28 (11), p.3383-3394
Hauptverfasser: Xu, Ricong, Li, Qibin, Liu, Rongjun, Shen, Juan, Li, Ming, Zhao, Minghui, Wang, Meng, Liao, Qijun, Mao, Haiping, Li, Zhijian, Zhou, Na, Yin, Peiran, Li, Yue, Tang, Xueqing, Wu, Tian, Zhong, Zhong, Wang, Yan, Ai, Zhen, Wang, Ou, Chen, Nan, Yang, Xiaoqin, Fang, Junbin, Fu, Ping, Gu, Jieruo, Ye, Kun, Chen, Jian, Dai, Lie, Liu, Huafeng, Liu, Zhangsuo, Liao, Yunhua, Wan, Jianxin, Ding, Guohua, Zhao, Jinghong, Zhang, Hao, Fu, Shuxia, Sun, Liangdan, Zhang, Xuejun, Yang, Huanming, Wang, Jian, Wang, Jun, Liu, Jianjun, Li, Yingrui, Yu, Xueqing
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Clinical Research
Female
Genome-Wide Association Study
Humans
Lupus Nephritis - genetics
Major Histocompatibility Complex - genetics
Male
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Beschreibung
Zusammenfassung:Lupus nephritis (LN) is one of the most prevalent and serious complications of SLE, with significant effects on patient and renal survival. Although a large number of genetic variants associated with SLE have been identified, biomarkers that correlate with LN are extremely limited. In this study, we performed a comprehensive sequencing analysis of the whole MHC region in 1331 patients with LN and 1296 healthy controls and validated the independent associations in another 950 patients with LN and 1000 controls. We discovered five independent risk variants for LN within the MHC region, including amino acid 11 (
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.2016121331