Quality of anticoagulation control and hemorrhage risk among African American and European American warfarin users

OBJECTIVEWe evaluated whether percent time in target range (PTTR), risk of over-anticoagulation [international normalized ratio (INR)>4], and risk of hemorrhage differ by race. As PTTR is a strong predictor of hemorrhage risk, we also determined the influence of PTTR on the risk of hemorrhage by...

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Veröffentlicht in:	Pharmacogenetics and genomics 2017-10, Vol.27 (10), p.347-355
Hauptverfasser:	Limdi, Nita A, Brown, Todd M, Shendre, Aditi, Liu, Nianjun, Hill, Charles E, Beasley, Timothy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult African Americans - genetics Aged Anticoagulants - adverse effects Anticoagulants - therapeutic use European Continental Ancestry Group - genetics Female Hemorrhage - etiology Humans Male Middle Aged Warfarin - adverse effects Warfarin - therapeutic use
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Zusammenfassung:	OBJECTIVEWe evaluated whether percent time in target range (PTTR), risk of over-anticoagulation [international normalized ratio (INR)>4], and risk of hemorrhage differ by race. As PTTR is a strong predictor of hemorrhage risk, we also determined the influence of PTTR on the risk of hemorrhage by race. PARTICIPANTS AND METHODSAmong 1326 warfarin users, PTTR was calculated as the percentage of interpolated INR values within the target range of 2.0–3.0. PTTR was also categorized as poor (PTTR
ISSN:	1744-6872 1744-6880
DOI:	10.1097/FPC.0000000000000298