Association of Structural and Functional Measures with Contrast Sensitivity in Glaucoma
Abstract PURPOSE To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN Cross-sectional prospective study. METHODS 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF)...
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| Veröffentlicht in: | American journal of ophthalmology 2017-06, Vol.178, p.129-139 |
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| creator | Fatehi, Nima Nowroozizadeh, Sara Henry, Sharon Coleman, Anne L Caprioli, Joseph Nouri-Mahdavi, Kouros |
| description | Abstract PURPOSE To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN Cross-sectional prospective study. METHODS 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses. RESULTS The median (IQR) 24-2 visual field mean deviation was −7.6 (−11.1 to −3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (ρ =0.222, p=0.023 and ρ =0.209, p=0.032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6x3 degree region (ρ =0.311, p=0.001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (ρ=−0.420; p |
| doi_str_mv | 10.1016/j.ajo.2017.03.019 |
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DESIGN Cross-sectional prospective study. METHODS 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses. RESULTS The median (IQR) 24-2 visual field mean deviation was −7.6 (−11.1 to −3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (ρ =0.222, p=0.023 and ρ =0.209, p=0.032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6x3 degree region (ρ =0.311, p=0.001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (ρ=−0.420; p<0.001). There was a significant correlation between logMAR visual acuity and contrast sensitivity at 6, 12, and 18 cpd (ρ =−0.306, −0.348 and −0.241, p<0.013, respectively). CONCLUSIONS Structural and functional measures showed a fair relationship with contrast sensitivity. This association was most prominent between full thickness macular measures or central VF parameters and CS at 6 cpd. Contrast sensitivity was not a reliable surrogate for glaucoma severity in this cross-sectional study.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2017.03.019</identifier><identifier>PMID: 28342719</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Algorithms ; Automation ; Contrast Sensitivity - physiology ; Cross-Sectional Studies ; Defects ; Diabetic retinopathy ; Disease Progression ; Female ; Glaucoma ; Glaucoma - diagnosis ; Glaucoma - physiopathology ; Humans ; Intraocular Pressure - physiology ; Male ; Medical imaging ; Ophthalmology ; Optics ; Patients ; Photoreceptors ; Prospective Studies ; Retina ; Retinal Ganglion Cells - pathology ; Software ; Tomography ; Tomography, Optical Coherence - methods ; Visual Acuity ; Visual Field Tests ; Visual Fields - physiology</subject><ispartof>American journal of ophthalmology, 2017-06, Vol.178, p.129-139</ispartof><rights>Elsevier Inc.</rights><rights>2017 Elsevier Inc.</rights><rights>Copyright © 2017 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 1, 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-38d79b74e13e53a53cd3e923f9bca7aa873d3c5bcd6949ba440fc874f86c52103</citedby><cites>FETCH-LOGICAL-c534t-38d79b74e13e53a53cd3e923f9bca7aa873d3c5bcd6949ba440fc874f86c52103</cites><orcidid>0000-0001-9403-8904</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajo.2017.03.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28342719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fatehi, Nima</creatorcontrib><creatorcontrib>Nowroozizadeh, Sara</creatorcontrib><creatorcontrib>Henry, Sharon</creatorcontrib><creatorcontrib>Coleman, Anne L</creatorcontrib><creatorcontrib>Caprioli, Joseph</creatorcontrib><creatorcontrib>Nouri-Mahdavi, Kouros</creatorcontrib><title>Association of Structural and Functional Measures with Contrast Sensitivity in Glaucoma</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Abstract PURPOSE To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN Cross-sectional prospective study. METHODS 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses. RESULTS The median (IQR) 24-2 visual field mean deviation was −7.6 (−11.1 to −3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (ρ =0.222, p=0.023 and ρ =0.209, p=0.032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6x3 degree region (ρ =0.311, p=0.001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (ρ=−0.420; p<0.001). There was a significant correlation between logMAR visual acuity and contrast sensitivity at 6, 12, and 18 cpd (ρ =−0.306, −0.348 and −0.241, p<0.013, respectively). CONCLUSIONS Structural and functional measures showed a fair relationship with contrast sensitivity. This association was most prominent between full thickness macular measures or central VF parameters and CS at 6 cpd. Contrast sensitivity was not a reliable surrogate for glaucoma severity in this cross-sectional study.</description><subject>Aged</subject><subject>Algorithms</subject><subject>Automation</subject><subject>Contrast Sensitivity - physiology</subject><subject>Cross-Sectional Studies</subject><subject>Defects</subject><subject>Diabetic retinopathy</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma - diagnosis</subject><subject>Glaucoma - physiopathology</subject><subject>Humans</subject><subject>Intraocular Pressure - physiology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Ophthalmology</subject><subject>Optics</subject><subject>Patients</subject><subject>Photoreceptors</subject><subject>Prospective Studies</subject><subject>Retina</subject><subject>Retinal Ganglion Cells - pathology</subject><subject>Software</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><subject>Visual Acuity</subject><subject>Visual Field Tests</subject><subject>Visual Fields - physiology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ksFu1DAQhi0EokvhAbigSFx6SbBjO46FVKla0YLUisOCerQcZ0IdsnaxnUX79jjatkAPPY1G882vmfkHobcEVwST5sNY6dFXNSaiwrTCRD5DK9IKWZJWkudohTGuS0klO0KvYhxz2ggmXqKjuqWsFkSu0PVZjN5Ynax3hR-KTQqzSXPQU6FdX5zPziylnF6BjnOAWPy26aZYe5eCjqnYgIs22Z1N-8K64mLSs_Fb_Rq9GPQU4c1dPEbfzz99W38uL79efFmfXZaGU5ZK2vZCdoIBocCp5tT0FGRNB9kZLbRuBe2p4Z3pG8lkpxnDg2kFG9rG8JpgeoxOD7q3c7eF3sAy1qRug93qsFdeW_V_xdkb9cPvFG8441JkgZM7geB_zRCT2tpoYJq0Az9HRdqWMCYIlxl9_wgd_RzybTIlMaFcMN5kihwoE3yMAYaHYQhWi21qVNk2tdimMFXZttzz7t8tHjrufcrAxwMA-ZY7C0FFY8EZ6G0Ak1Tv7ZPyp4-6zWSdNXr6CXuIf7dQsVZYbZa_Wd6GCIpJLQT9A6O3voY</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Fatehi, Nima</creator><creator>Nowroozizadeh, Sara</creator><creator>Henry, Sharon</creator><creator>Coleman, Anne L</creator><creator>Caprioli, Joseph</creator><creator>Nouri-Mahdavi, Kouros</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9403-8904</orcidid></search><sort><creationdate>20170601</creationdate><title>Association of Structural and Functional Measures with Contrast Sensitivity in Glaucoma</title><author>Fatehi, Nima ; Nowroozizadeh, Sara ; Henry, Sharon ; Coleman, Anne L ; Caprioli, Joseph ; Nouri-Mahdavi, Kouros</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-38d79b74e13e53a53cd3e923f9bca7aa873d3c5bcd6949ba440fc874f86c52103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Algorithms</topic><topic>Automation</topic><topic>Contrast Sensitivity - physiology</topic><topic>Cross-Sectional Studies</topic><topic>Defects</topic><topic>Diabetic retinopathy</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Glaucoma</topic><topic>Glaucoma - diagnosis</topic><topic>Glaucoma - physiopathology</topic><topic>Humans</topic><topic>Intraocular Pressure - physiology</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Ophthalmology</topic><topic>Optics</topic><topic>Patients</topic><topic>Photoreceptors</topic><topic>Prospective Studies</topic><topic>Retina</topic><topic>Retinal Ganglion Cells - pathology</topic><topic>Software</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - methods</topic><topic>Visual Acuity</topic><topic>Visual Field Tests</topic><topic>Visual Fields - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fatehi, Nima</creatorcontrib><creatorcontrib>Nowroozizadeh, Sara</creatorcontrib><creatorcontrib>Henry, Sharon</creatorcontrib><creatorcontrib>Coleman, Anne L</creatorcontrib><creatorcontrib>Caprioli, Joseph</creatorcontrib><creatorcontrib>Nouri-Mahdavi, Kouros</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fatehi, Nima</au><au>Nowroozizadeh, Sara</au><au>Henry, Sharon</au><au>Coleman, Anne L</au><au>Caprioli, Joseph</au><au>Nouri-Mahdavi, Kouros</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Structural and Functional Measures with Contrast Sensitivity in Glaucoma</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>178</volume><spage>129</spage><epage>139</epage><pages>129-139</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>Abstract PURPOSE To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN Cross-sectional prospective study. METHODS 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses. RESULTS The median (IQR) 24-2 visual field mean deviation was −7.6 (−11.1 to −3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (ρ =0.222, p=0.023 and ρ =0.209, p=0.032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6x3 degree region (ρ =0.311, p=0.001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (ρ=−0.420; p<0.001). There was a significant correlation between logMAR visual acuity and contrast sensitivity at 6, 12, and 18 cpd (ρ =−0.306, −0.348 and −0.241, p<0.013, respectively). CONCLUSIONS Structural and functional measures showed a fair relationship with contrast sensitivity. This association was most prominent between full thickness macular measures or central VF parameters and CS at 6 cpd. Contrast sensitivity was not a reliable surrogate for glaucoma severity in this cross-sectional study.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28342719</pmid><doi>10.1016/j.ajo.2017.03.019</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9403-8904</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Algorithms Automation Contrast Sensitivity - physiology Cross-Sectional Studies Defects Diabetic retinopathy Disease Progression Female Glaucoma Glaucoma - diagnosis Glaucoma - physiopathology Humans Intraocular Pressure - physiology Male Medical imaging Ophthalmology Optics Patients Photoreceptors Prospective Studies Retina Retinal Ganglion Cells - pathology Software Tomography Tomography, Optical Coherence - methods Visual Acuity Visual Field Tests Visual Fields - physiology |
| title | Association of Structural and Functional Measures with Contrast Sensitivity in Glaucoma |
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