Association of Structural and Functional Measures with Contrast Sensitivity in Glaucoma

Abstract PURPOSE To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN Cross-sectional prospective study. METHODS 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses. RESULTS The median (IQR) 24-2 visual field mean deviation was −7.6 (−11.1 to −3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (ρ =0.222, p=0.023 and ρ =0.209, p=0.032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6x3 degree region (ρ =0.311, p=0.001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (ρ=−0.420; p