Acyclic Quaternary Carbon Stereocenters via Enantioselective Transition Metal Catalysis

Acyclic Quaternary Carbon Stereocenters via Enantioselective Transition Metal Catalysis

Whereas numerous asymmetric methods for formation of quaternary carbon stereocenters in cyclic systems have been documented, the construction of acyclic quaternary carbon stereocenters with control of absolute stereochemistry remains a formidable challenge. This Review summarizes enantioselective me...

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Veröffentlicht in:Chemical reviews 2017-10, Vol.117 (19), p.12564-12580
Hauptverfasser: Feng, Jiajie, Holmes, Michael, Krische, Michael J
Format: Artikel
Sprache:eng
Schlagworte:
Carbon
Catalysis
catalytic activity
Construction
Construction methods
enantioselectivity
Metals
Stereochemistry
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Zusammenfassung:Whereas numerous asymmetric methods for formation of quaternary carbon stereocenters in cyclic systems have been documented, the construction of acyclic quaternary carbon stereocenters with control of absolute stereochemistry remains a formidable challenge. This Review summarizes enantioselective methods for the construction of acyclic quaternary carbon stereocenters from achiral or chiral racemic reactants via transition metal catalysis.
ISSN:0009-2665
1520-6890
1520-6890
DOI:10.1021/acs.chemrev.7b00385