Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

Phyllomeroterpenoids A−C ( 1 − 3 ), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds ( 4 − 9 ). All structures were det...

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Veröffentlicht in:Scientific reports 2017-10, Vol.7 (1), p.12925-8, Article 12925
Hauptverfasser: Yang, Heng-Gang, Zhao, Huan, Li, Jiao-Jiao, Chen, Shao-Meng, Mou, Lang-Ming, Zou, Jian, Chen, Guo-Dong, Qin, Sheng-Ying, Wang, Chuan-Xi, Hu, Dan, Yao, Xin-Sheng, Gao, Hao
Format: Artikel
Sprache:eng
Schlagworte:
140/131
631/92/349
631/92/613
Amino acids
Endophytes
Fungi
Humanities and Social Sciences
multidisciplinary
Pentose phosphate pathway
Science
Science (multidisciplinary)
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Zusammenfassung:Phyllomeroterpenoids A−C ( 1 − 3 ), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds ( 4 − 9 ). All structures were determined by extensive spectroscopic analysis, chemical derivatization, and ECD experiments. A plausible biosynthetic pathway of 1 − 3 was proposed. In addition, the antimicrobial activities of all isolated compounds were evaluated against Staphylococcus aureus 209P (bacterium) and Candida albicans FIM709 (fungus).
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-13407-y