Effect of Sofosbuvir-Based Hepatitis C Virus Therapy on Kidney Function in Patients with CKD

Effect of Sofosbuvir-Based Hepatitis C Virus Therapy on Kidney Function in Patients with CKD

Hepatitis C virus infection is common in patients with CKD and leads to accelerated progression to ESRD. Sofosbuvir is a potent direct-acting antiviral therapy against hepatitis C virus; however, there are concerns about its safety in patients with CKD. The objective of our study was to determine th...

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Veröffentlicht in:Clinical journal of the American Society of Nephrology 2017-10, Vol.12 (10), p.1615-1623
Hauptverfasser: Sise, Meghan E, Backman, Elke, Ortiz, Guillermo A, Hundemer, Gregory L, Ufere, Nneka N, Chute, Donald F, Brancale, Joseph, Xu, Dihua, Wisocky, Jessica, Lin, Ming V, Kim, Arthur Y, Thadhani, Ravi, Chung, Raymond T
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Albuminuria - complications
Albuminuria - physiopathology
Antiviral Agents - adverse effects
Antiviral Agents - therapeutic use
Drug Therapy, Combination
Female
Glomerular Filtration Rate - drug effects
Hepatitis C - complications
Hepatitis C - diagnosis
Hepatitis C - drug therapy
Humans
Kidney - drug effects
Kidney - physiopathology
Male
Middle Aged
Original
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - physiopathology
Retrospective Studies
Risk Factors
Sofosbuvir - adverse effects
Sofosbuvir - therapeutic use
Sustained Virologic Response
Time Factors
Treatment Outcome
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Zusammenfassung:Hepatitis C virus infection is common in patients with CKD and leads to accelerated progression to ESRD. Sofosbuvir is a potent direct-acting antiviral therapy against hepatitis C virus; however, there are concerns about its safety in patients with CKD. The objective of our study was to determine the safety and efficacy of sofosbuvir in patients with CKD. We studied a retrospective observational cohort of patients with CKD defined by eGFR
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.02510317