HOXD-AS1 functions as an oncogenic ceRNA to promote NSCLC cell progression by sequestering miR-147a

Non-small cell lung cancer (NSCLC) is one of the most common malignancies worldwide, and it occurs at a higher frequency in males. HOXD-AS1, an important cancer-associated long noncoding RNA (lncRNA), contributes to the development and progression of several cancers. However, the exact roles of HOXD...

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Veröffentlicht in:	OncoTargets and therapy 2017-01, Vol.10, p.4753-4763
Hauptverfasser:	Wang, Qinghua, Jiang, Shujun, Song, Anying, Hou, Siyuan, Wu, Qinfeng, Qi, Longju, Gao, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense RNA Apoptosis Care and treatment Cloning Development and progression Gene expression Genetic aspects Genomes Genomics Health aspects Laboratories Liver cancer Lung cancer Metastasis MicroRNAs Mutation Neuroblastoma Non-small cell lung cancer Non-small cell lung carcinoma Original Research Plasmids Proteins Transcription factors Tuberculosis Tumors
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Zusammenfassung:	Non-small cell lung cancer (NSCLC) is one of the most common malignancies worldwide, and it occurs at a higher frequency in males. HOXD-AS1, an important cancer-associated long noncoding RNA (lncRNA), contributes to the development and progression of several cancers. However, the exact roles of HOXD-AS1 in NSCLC progression are still unknown. Here, we investigated the underlying mechanisms of HOXD-AS1 in human NSCLC tissues. We found that lncRNA HOXD-AS1 was specifically upregulated (
ISSN:	1178-6930 1178-6930
DOI:	10.2147/OTT.S143787