Multicellular Vascularized Engineered Tissues through User‐Programmable Biomaterial Photodegradation

A photodegradable material‐based approach to generate endothelialized 3D vascular networks within cell‐laden hydrogel biomaterials is introduced. Exploiting multiphoton lithography, microchannel networks spanning nearly all size scales of native human vasculature are readily generated with unprecedented user‐defined 4D control. Intraluminal channel architectures of synthetic vessels are fully customizable, providing new opportunities for next‐generation microfluidics and directed cell function. A photodegradable material‐based approach to generate endothelialized 3D vascular networks within cell‐laden hydrogel biomaterials is introduced. Exploiting multiphoton lithography, microchannel networks spanning size scales of nearly all native human vasculature are readily generated with unprecedented user‐defined 4D control. Intraluminal channel architectures of synthetic vessels are fully customizable, providing new opportunities for next‐generation microfluidics and directed cell function.