Catch and release: 14-3-3 controls Ncd in meiotic spindles

During oogenesis, spindle assembly occurs without centrosomes and relies on signals from chromosomes. Beaven et al. (2017. https://doi.org/10.1083/jcb.201704120) show that 14-3-3 proteins bind and inhibit a key microtubule motor, Ncd, during oogenesis, but Aurora B releases Ncd inhibition near chrom...

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Veröffentlicht in:	The Journal of cell biology 2017-10, Vol.216 (10), p.3003-3005
1. Verfasser:	Dasso, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	14-3-3 protein Animals Aurora B protein Cell division Centrosomes Chromosomes Drosophila melanogaster - genetics Drosophila Proteins - genetics Fruit flies Gametes Kinesin - genetics Meiosis Microtubules Oocytes Oogenesis Proteins Reproduction Reproduction (biology) Sexual reproduction Spindle Apparatus - genetics Spindles
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Beschreibung
Zusammenfassung:	During oogenesis, spindle assembly occurs without centrosomes and relies on signals from chromosomes. Beaven et al. (2017. https://doi.org/10.1083/jcb.201704120) show that 14-3-3 proteins bind and inhibit a key microtubule motor, Ncd, during oogenesis, but Aurora B releases Ncd inhibition near chromosomes, allowing Ncd to work in the right time and place.
ISSN:	0021-9525 1540-8140
DOI:	10.1083/jcb.201708036