Maternal residential air pollution and placental imprinted gene expression
Maternal exposure to air pollution is associated with reduced fetal growth, but its relationship with expression of placental imprinted genes (important regulators of fetal growth) has not yet been studied. To examine relationships between maternal residential air pollution and expression of placent...
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Veröffentlicht in: | Environment international 2017-11, Vol.108, p.204-211 |
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Zusammenfassung: | Maternal exposure to air pollution is associated with reduced fetal growth, but its relationship with expression of placental imprinted genes (important regulators of fetal growth) has not yet been studied.
To examine relationships between maternal residential air pollution and expression of placental imprinted genes in the Rhode Island Child Health Study (RICHS).
Women-infant pairs were enrolled following delivery between 2009 and 2013. We geocoded maternal residential addresses at delivery, estimated daily levels of fine particulate matter (PM2.5; n=355) and black carbon (BC; n=336) using spatial-temporal models, and estimated residential distance to nearest major roadway (n=355). Using linear regression models we investigated the associations between each exposure metric and expression of nine candidate genes previously associated with infant birthweight in RICHS, with secondary analyses of a panel of 108 imprinted genes expressed in the placenta. We also explored effect measure modification by infant sex.
PM2.5 and BC were associated with altered expression for seven and one candidate genes, respectively, previously linked with birthweight in this cohort. Adjusting for multiple comparisons, we found that PM2.5 and BC were associated with changes in expression of 41 and 12 of 108 placental imprinted genes, respectively. Infant sex modified the association between PM2.5 and expression of CHD7 and between proximity to major roadways and expression of ZDBF2.
We found that maternal exposure to residential PM2.5 and BC was associated with changes in placental imprinted gene expression, which suggests a plausible line of investigation of how air pollution affects fetal growth and development.
•The mechanism by which air pollution exposure impacts fetal growth remains unknown.•Placental imprinted genes are important regulators of fetal growth.•Air pollution exposure and expression of placental imprinted genes was studied.•Air pollution was associated with changes in placental imprinted gene expression.•This suggests a potential mechanism of how air pollution may affect fetal growth. |
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ISSN: | 0160-4120 1873-6750 |
DOI: | 10.1016/j.envint.2017.08.022 |