Behavioral and physiological consequences of enrichment loss in rats

Highlights • Environmental enrichment removal induces depression-like behavior and weight gain in rats. • Enrichment removal blunts peak glucocorticoid response to acute stress. • Enrichment removal increases intake of chow, sucrose, and high fat diet. • Enrichment removal effects are prevented with...

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Veröffentlicht in:	Psychoneuroendocrinology 2017-03, Vol.77, p.37-46
Hauptverfasser:	Smith, Brittany L, Lyons, Carey E, Correa, Fernanda Guilhaume, Benoit, Stephen C, Myers, Brent, Solomon, Matia B, Herman, James P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Antidepressive Agents - therapeutic use Behavior, Animal - drug effects Behavior, Animal - physiology Depression Depression - drug therapy Depression - physiopathology Diet Disease Models, Animal Endocrinology & Metabolism Environment Environmental enrichment Feeding Behavior - physiology Housing, Animal Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiopathology Imipramine Loss Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiopathology Psychiatry Rats Reward Social Behavior Stress Stress, Psychological - drug therapy Stress, Psychological - physiopathology Weight gain
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Zusammenfassung:	Highlights • Environmental enrichment removal induces depression-like behavior and weight gain in rats. • Enrichment removal blunts peak glucocorticoid response to acute stress. • Enrichment removal increases intake of chow, sucrose, and high fat diet. • Enrichment removal effects are prevented with antidepressant treatment. • Enrichment removal effects are not recapitulated by loss of other stimuli.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2016.11.040