Avibactam Restores the Susceptibility of Clinical Isolates of Stenotrophomonas maltophilia to Aztreonam

is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for is urgent. We demonstrate the efficacy of aztreonam-avibactam (ATM-AVI) a...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2017-10, Vol.61 (10)
Hauptverfasser:	Mojica, Maria F, Papp-Wallace, Krisztina M, Taracila, Magdalena A, Barnes, Melissa D, Rutter, Joseph D, Jacobs, Michael R, LiPuma, John J, Walsh, Thomas J, Vila, Alejandro J, Bonomo, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Anti-Bacterial Agents - pharmacology Azabicyclo Compounds Azabicyclo Compounds - pharmacology Aztreonam Aztreonam - pharmacology beta-Lactamase Inhibitors beta-Lactamase Inhibitors - pharmacology beta-Lactamases beta-Lactamases - drug effects Drug Combinations Drug Resistance, Multiple, Bacterial - drug effects Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - microbiology Humans Mechanisms of Resistance Microbial Sensitivity Tests Stenotrophomonas maltophilia Stenotrophomonas maltophilia - drug effects Stenotrophomonas maltophilia - isolation & purification
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Zusammenfassung:	is an emerging opportunistic pathogen, classified by the World Health Organization as one of the leading multidrug-resistant organisms in hospital settings. The need to discover novel compounds and/or combination therapies for is urgent. We demonstrate the efficacy of aztreonam-avibactam (ATM-AVI) against and kinetically characterize the inhibition of the L2 β-lactamase by avibactam. ATM-AVI overcomes aztreonam resistance in selected clinical strains of , addressing an unmet medical need.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.00777-17