A CRISPR Approach to Neurodegenerative Diseases

A major barrier to developing effective therapies for neurodegenerative diseases is our incomplete understanding of the underlying cellular mechanisms. Genetic screens in human-induced pluripotent stem cell-derived neurons can elucidate such mechanisms. Genome-wide screens using CRISPR interference...

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Veröffentlicht in:	Trends in molecular medicine 2017-06, Vol.23 (6), p.483-485
1. Verfasser:	Kampmann, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation CRISPR-Cas Systems Humans Induced Pluripotent Stem Cells - metabolism Neurodegenerative Diseases - genetics Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - therapy Neurons - metabolism Pathology
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Beschreibung
Zusammenfassung:	A major barrier to developing effective therapies for neurodegenerative diseases is our incomplete understanding of the underlying cellular mechanisms. Genetic screens in human-induced pluripotent stem cell-derived neurons can elucidate such mechanisms. Genome-wide screens using CRISPR interference and CRISPR activation provide complementary biological insights and may reveal potential therapeutic targets.
ISSN:	1471-4914 1471-499X
DOI:	10.1016/j.molmed.2017.04.003