Duration of Androgen Deprivation in Locally Advanced Prostate Cancer: Long-Term Update of NRG Oncology RTOG 9202

Abstract Purpose Trial*** was a phase III randomized trial designed to determine the optimal duration of androgen deprivation therapy (ADT) when combined with definitive radiation therapy (RT) in the treatment of locally advanced non-metastatic adenocarcinoma of the prostate. Long-term follow-up res...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2017-06, Vol.98 (2), p.296-303
Hauptverfasser:	Lawton, Colleen A.F., MD, Lin, Xiaolei, MS, Hanks, Gerald E., MD, Lepor, Herbert, MD, Grignon, David J., MD, Brereton, Harmar D., MD, Bedi, Meena, MD, Rosenthal, Seth A., MD, Zeitzer, Kenneth L., MD, Venkatesan, Varagur M., MD, Horwitz, Eric M., MD, Pisansky, Thomas M., MD, Kim, Harold, MD, Parliament, Matthew B., MD, Rabinovitch, Rachel, MD, Roach, Mack, MD, Kwok, Young, MD, Dignam, James J., PhD, Sandler, Howard M., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - therapy Adult Aged Aged, 80 and over Androgen Antagonists - administration & dosage Androgen Antagonists - adverse effects Androgen Antagonists - therapeutic use ANDROGENS Combined Modality Therapy - adverse effects Combined Modality Therapy - methods Combined Modality Therapy - statistics & numerical data Disease-Free Survival Flutamide - administration & dosage Flutamide - adverse effects Flutamide - therapeutic use Follow-Up Studies Goserelin - administration & dosage Goserelin - adverse effects Goserelin - therapeutic use Hematology, Oncology and Palliative Medicine Humans Male Middle Aged NEOPLASMS PROSTATE Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - mortality Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Time Factors Treatment Outcome
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Zusammenfassung:	Abstract Purpose Trial*** was a phase III randomized trial designed to determine the optimal duration of androgen deprivation therapy (ADT) when combined with definitive radiation therapy (RT) in the treatment of locally advanced non-metastatic adenocarcinoma of the prostate. Long-term follow-up results of this study now available are relevant to the management of this disease. Materials and Methods Men (N=1,554) with adenocarcinoma of the prostate (cT2c-T4, N0-Nx) with a prostate specific antigen (PSA)
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2017.02.004