Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults

Background. Obesity exacerbates age-related decline in glucometabolic control. Undercarboxylated osteocalcin (UcOC) regulates pancreatic insulin secretion. The long-term effect of lifestyle interventions on UcOC and insulin secretion has not been investigated. Methods. One hundred seven frail, obese...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-12
Hauptverfasser:	Armamento-Villareal, Reina, Phadnis, Uma, Napoli, Nicola, Colleluori, Georgia, Villareal, Dennis T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of daily living Age Aged Body composition Care and treatment Clinical Study Development and progression Diabetes Diet Endocrinology Exercise Exercise - physiology Female Fitness training programs Frail Elderly Frailty Glucose Health aspects Humans Insulin Insulin - metabolism Insulin resistance Lifestyles Male Metabolism Musculoskeletal system Obesity Obesity - therapy Older people Osteocalcin - metabolism Oxidative stress Physiology Population Rodents Studies Weight control Weight Loss - physiology
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Zusammenfassung:	Background. Obesity exacerbates age-related decline in glucometabolic control. Undercarboxylated osteocalcin (UcOC) regulates pancreatic insulin secretion. The long-term effect of lifestyle interventions on UcOC and insulin secretion has not been investigated. Methods. One hundred seven frail, obese older adults were randomized into the control (N=27), diet (N=26), exercise (N=26), and diet-exercise (N=28) groups for 1 year. Main outcomes included changes in UcOC and disposition index (DI). Results. UcOC increased in the diet group (36 ± 11.6%) but not in the other groups (P
ISSN:	1942-0900 1942-0994
DOI:	10.1155/2017/4807046