Myocardial Native T1 Time in Patients with Hypertrophic Cardiomyopathy

Abstract In hypertrophic cardiomyopathy (HC), there are significant variations in left ventricular (LV) wall thickness and fibrosis, which necessitates a volumetric coverage. Slice-interleaved T1 (STONE) mapping sequence allows for the assessment of native T1 time with complete coverage of LV myocar...

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Veröffentlicht in:The American journal of cardiology 2016-10, Vol.118 (7), p.1057-1062
Hauptverfasser: Kato, Shingo, MD, Nakamori, Shiro, MD, Bellm, Steven, MD, Jang, Jihye, MSc, Basha, Tamer, PhD, Maron, Martin, MD, Manning, Warren J., MD, Nezafat, Reza, PhD
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Sprache:eng
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Zusammenfassung:Abstract In hypertrophic cardiomyopathy (HC), there are significant variations in left ventricular (LV) wall thickness and fibrosis, which necessitates a volumetric coverage. Slice-interleaved T1 (STONE) mapping sequence allows for the assessment of native T1 time with complete coverage of LV myocardium. The aims of this study was to evaluate spatial heterogeneity of native T1 time in HC patients. Twenty-nine HC patients (55±16 years) and 15 healthy adult control subjects (46±19 years) were studied. Native T1 mapping was performed using STONE sequence which enables acquisition of 5 slices in the short-axis plane within a 90 sec free-breathing scan. We measured LV native T1 time and maximum LV wall thickness in each 16 segments from 3 slices (basal, mid-ventricular and apical-slice). Late gadolinium enhanced (LGE) MRI was acquired to assess presence of myocardial enhancement. In HC patients, LV native T1 time was significantly elevated compared to healthy controls, regardless of presence or absence of LGE (mean native T1 time; LGE positive segments from HC, 1141±46 msec; LGE negative segments from HC, 1114±56 msec; segments from healthy controls, 1065±35 msec, p1135 msec, which was +2SD of native T1 time by STONE sequence in healthy controls. 120 of 405 (30%) LGE negative segments from HC patients showed elevated native T1 time. Prevalence of segments with elevated native T1 time for basal, mid-ventricular and apical slice was 29%, 25%, 38%, respectively. Significant correlation was found between LV wall thickness and LV native T1 time (y=0.029x-22.6, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2016.07.010