Rho GTPases as therapeutic targets in cancer (Review)

Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of t...

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Veröffentlicht in:	International journal of oncology 2017-10, Vol.51 (4), p.1025-1034
Hauptverfasser:	Cardama, G A, Gonzalez, N, Maggio, J, Menna, P Lorenzano, Gomez, D E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cancer Cell adhesion & migration Cell cycle Drugs Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Epidermal growth factor Gene expression Humans Kinases Molecular Targeted Therapy Morphology Neoplasms - drug therapy Neoplasms - enzymology Proteins rho GTP-Binding Proteins - antagonists & inhibitors rho GTP-Binding Proteins - metabolism Signal transduction
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Beschreibung
Zusammenfassung:	Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets.
ISSN:	1019-6439 1791-2423
DOI:	10.3892/ijo.2017.4093