Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis

Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis

The phosphorylated epidermal growth factor receptor (P-EGFR) and phosphorylated Akt (P-Akt) protein in esophageal squamous cell carcinoma (ESCC) were studied, and its significance in clinical prognosis of patients was assessed. The expression of P-EGFR and P-Akt protein in 83 cases of ESCC and 83 no...

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Veröffentlicht in:Oncology letters 2017-09, Vol.14 (3), p.2859-2863
Hauptverfasser: Shan, Zheng-Zheng, Chen, Pei-Nan, Wang, Feng, Wang, Jun, Fan, Qing-Xia
Format: Artikel
Sprache:eng
Schlagworte:
Biotechnology
Cancer therapies
Care and treatment
Cytoplasm
Development and progression
Epidermal growth factor
Esophageal cancer
esophageal carcinoma
Gene expression
Genetic aspects
Health aspects
immunohistochemistry
Kinases
Lymphatic system
Medical prognosis
Metastasis
Pathogenesis
phosphorylated Akt
phosphorylated epidermal growth factor receptor
prognosis
Protein expression
Proteins
Squamous cell carcinoma
Studies
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Zusammenfassung:The phosphorylated epidermal growth factor receptor (P-EGFR) and phosphorylated Akt (P-Akt) protein in esophageal squamous cell carcinoma (ESCC) were studied, and its significance in clinical prognosis of patients was assessed. The expression of P-EGFR and P-Akt protein in 83 cases of ESCC and 83 normal esophageal tissues was determined by immunohistochemical staining. Log-rank test and correlation analysis were used to analyze the prognosis of ESCC. The positive expression of P-EGFR in ESCC was 88% (73/83 cases) compared with 41% in normal esophageal mucosa (34/83 cases) (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2017.6526