O-GlcNAcylation Reduces Ischemia-Reperfusion–Induced Brain Injury

O-GlcNAcylation Reduces Ischemia-Reperfusion–Induced Brain Injury

O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins with β-N-acetylglucosamine (GlcNAc) and regulates numerous biological processes. By using mouse models of cerebral ischemia induced by permanent and transient middle cerebral artery occlusion (MCAO), we observed...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports 2017-09, Vol.7 (1), p.10686-12, Article 10686
Hauptverfasser: Gu, Jin-hua, Shi, Jianhua, Dai, Chun-ling, Ge, Jian-bin, Zhao, Yang, Chen, Yanxing, Yu, Qian, Qin, Zheng-hong, Iqbal, Khalid, Liu, Fei, Gong, Cheng-Xin
Format: Artikel
Sprache:eng
Schlagworte:
631/378/1934
631/378/87
64
64/60
Animal models
Brain
Brain injury
Cerebral blood flow
Humanities and Social Sciences
Ischemia
multidisciplinary
N-Acetylglucosamine
Neurological diseases
O-GlcNAcylation
Reperfusion
Rodents
Science
Science (multidisciplinary)
Stroke
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:O-GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins with β-N-acetylglucosamine (GlcNAc) and regulates numerous biological processes. By using mouse models of cerebral ischemia induced by permanent and transient middle cerebral artery occlusion (MCAO), we observed an initial elevation (~1.7-fold, 1–4 hours after ischemia) and then decline of O-GlcNAcylation during cerebral ischemia. We found that moderate increase (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-10635-0