Cholecalciferol, Calcitriol, and Vascular Function in CKD: A Randomized, Double-Blind Trial

High circulating vitamin D levels are associated with lower cardiovascular mortality in CKD, possibly by modifying endothelial function. We examined the effect of calcitriol versus cholecalciferol supplementation on vascular endothelial function in patients with CKD. We performed a prospective, doub...

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Veröffentlicht in:	Clinical journal of the American Society of Nephrology 2017-09, Vol.12 (9), p.1438-1446
Hauptverfasser:	Kendrick, Jessica, Andrews, Emily, You, Zhiying, Moreau, Kerrie, Nowak, Kristen L, Farmer-Bailey, Heather, Seals, Douglas R, Chonchol, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biomarkers - blood Brachial Artery - drug effects Brachial Artery - metabolism Brachial Artery - physiopathology Calcitriol - adverse effects Calcitriol - therapeutic use Cholecalciferol - adverse effects Cholecalciferol - therapeutic use Colorado Dietary Supplements - adverse effects Double-Blind Method Female Glomerular Filtration Rate - drug effects Humans Inflammation Mediators - blood Kidney - drug effects Kidney - physiopathology Male Middle Aged Original Prospective Studies Recovery of Function Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - physiopathology Time Factors Treatment Outcome Vasodilation - drug effects Vitamin D - analogs & derivatives Vitamin D - blood
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Zusammenfassung:	High circulating vitamin D levels are associated with lower cardiovascular mortality in CKD, possibly by modifying endothelial function. We examined the effect of calcitriol versus cholecalciferol supplementation on vascular endothelial function in patients with CKD. We performed a prospective, double-blind, randomized trial of 128 adult patients with eGFR=15-44 ml/min per 1.73 m and serum 25-hydroxyvitamin D level
ISSN:	1555-9041 1555-905X
DOI:	10.2215/CJN.01870217