Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD

Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD

BACKGROUND AND OBJECTIVESVitamin D supplements are prescribed to correct low circulating concentrations of 25-hydroxyvitamin D. In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hyd...

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Veröffentlicht in:Clinical journal of the American Society of Nephrology 2017-09, Vol.12 (9), p.1498-1506
Hauptverfasser: Batacchi, Zona, Robinson-Cohen, Cassianne, Hoofnagle, Andrew N., Isakova, Tamara, Kestenbaum, Bryan, Martin, Kevin J., Wolf, Myles S., de Boer, Ian H.
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Sprache:eng
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Zusammenfassung:BACKGROUND AND OBJECTIVESVitamin D supplements are prescribed to correct low circulating concentrations of 25-hydroxyvitamin D. In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D by CYP24A1. The aim of this study was to determine the effects of vitamin D2 supplementation on vitamin D metabolism in health and CKD.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTSWe conducted a treatment-only intervention study of 25 individuals with CKD (eGFR
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.00530117