Membrane Transport across Polarized Epithelia

Polarized epithelial cells line diverse surfaces throughout the body forming selective barriers between the external environment and the internal milieu. To cross these epithelial barriers, large solutes and other cargoes must undergo transcytosis, an endocytic pathway unique to polarized cell types...

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Veröffentlicht in:Cold Spring Harbor perspectives in biology 2017-09, Vol.9 (9), p.a027912
Hauptverfasser: Garcia-Castillo, Maria Daniela, Chinnapen, Daniel J-F, Lencer, Wayne I
Format: Artikel
Sprache:eng
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Zusammenfassung:Polarized epithelial cells line diverse surfaces throughout the body forming selective barriers between the external environment and the internal milieu. To cross these epithelial barriers, large solutes and other cargoes must undergo transcytosis, an endocytic pathway unique to polarized cell types, and significant for the development of cell polarity, uptake of viral and bacterial pathogens, transepithelial signaling, and immunoglobulin transport. Here, we review recent advances in our knowledge of the transcytotic pathway for proteins and lipids. We also discuss briefly the promise of harnessing the molecules that undergo transcytosis as vehicles for clinical applications in drug delivery.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a027912