A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen–recognition properties
Type I natural killer T cells are characterized by an invariant V α 14-J α 18 T cell antigen receptor α-chain. Godfrey and colleagues describe a population of CD1d-restricted natural killer T cells that express a previously unidentified canonical V α 10-J α 50 α-chain. Type I natural killer T cells...
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| Veröffentlicht in: | Nature immunology 2011-06, Vol.12 (7), p.616-623 |
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| creator | Uldrich, Adam P Patel, Onisha Cameron, Garth Pellicci, Daniel G Day, E Bridie Sullivan, Lucy C Kyparissoudis, Konstantinos Kjer-Nielsen, Lars Vivian, Julian P Cao, Benjamin Brooks, Andrew G Williams, Spencer J Illarionov, Petr Besra, Gurdyal S Turner, Stephen J Porcelli, Steven A McCluskey, James Smyth, Mark J Rossjohn, Jamie Godfrey, Dale I |
| description | Type I natural killer T cells are characterized by an invariant V
α
14-J
α
18 T cell antigen receptor α-chain. Godfrey and colleagues describe a population of CD1d-restricted natural killer T cells that express a previously unidentified canonical V
α
10-J
α
50 α-chain.
Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14–joining region 18 (V
α
14-J
α
18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical V
α
10-J
α
50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid–containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the V
α
10 TCR–CD1d–α-GlcCer complex had a docking mode similar to that of type I TCR–CD1d–α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses. |
| doi_str_mv | 10.1038/ni.2051 |
| format | Article |
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α
14-J
α
18 T cell antigen receptor α-chain. Godfrey and colleagues describe a population of CD1d-restricted natural killer T cells that express a previously unidentified canonical V
α
10-J
α
50 α-chain.
Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14–joining region 18 (V
α
14-J
α
18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical V
α
10-J
α
50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid–containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the V
α
10 TCR–CD1d–α-GlcCer complex had a docking mode similar to that of type I TCR–CD1d–α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni.2051</identifier><identifier>PMID: 21666690</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/250/1619/554/383 ; 631/535 ; Adjuvants, Immunologic - pharmacology ; Amino Acid Sequence ; Animals ; Antigens, Bacterial - immunology ; Antigens, CD1d - immunology ; Biomedical and Life Sciences ; Biomedicine ; Cell Line ; Galactosylceramides - immunology ; Galactosylceramides - pharmacology ; Glucuronates - immunology ; Humans ; Immunology ; Infectious Diseases ; Mice ; Mice, Mutant Strains ; Molecular Sequence Data ; Natural Killer T-Cells - immunology ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><ispartof>Nature immunology, 2011-06, Vol.12 (7), p.616-623</ispartof><rights>Springer Nature America, Inc. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c331t-e8239b2eba2244f8dac70ad34f1c641d8394ddb128aa4eb95e98ab4b17387b8c3</citedby><cites>FETCH-LOGICAL-c331t-e8239b2eba2244f8dac70ad34f1c641d8394ddb128aa4eb95e98ab4b17387b8c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21666690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uldrich, Adam P</creatorcontrib><creatorcontrib>Patel, Onisha</creatorcontrib><creatorcontrib>Cameron, Garth</creatorcontrib><creatorcontrib>Pellicci, Daniel G</creatorcontrib><creatorcontrib>Day, E Bridie</creatorcontrib><creatorcontrib>Sullivan, Lucy C</creatorcontrib><creatorcontrib>Kyparissoudis, Konstantinos</creatorcontrib><creatorcontrib>Kjer-Nielsen, Lars</creatorcontrib><creatorcontrib>Vivian, Julian P</creatorcontrib><creatorcontrib>Cao, Benjamin</creatorcontrib><creatorcontrib>Brooks, Andrew G</creatorcontrib><creatorcontrib>Williams, Spencer J</creatorcontrib><creatorcontrib>Illarionov, Petr</creatorcontrib><creatorcontrib>Besra, Gurdyal S</creatorcontrib><creatorcontrib>Turner, Stephen J</creatorcontrib><creatorcontrib>Porcelli, Steven A</creatorcontrib><creatorcontrib>McCluskey, James</creatorcontrib><creatorcontrib>Smyth, Mark J</creatorcontrib><creatorcontrib>Rossjohn, Jamie</creatorcontrib><creatorcontrib>Godfrey, Dale I</creatorcontrib><title>A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen–recognition properties</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><addtitle>Nat Immunol</addtitle><description>Type I natural killer T cells are characterized by an invariant V
α
14-J
α
18 T cell antigen receptor α-chain. Godfrey and colleagues describe a population of CD1d-restricted natural killer T cells that express a previously unidentified canonical V
α
10-J
α
50 α-chain.
Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14–joining region 18 (V
α
14-J
α
18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical V
α
10-J
α
50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid–containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the V
α
10 TCR–CD1d–α-GlcCer complex had a docking mode similar to that of type I TCR–CD1d–α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.</description><subject>631/250/1619/554/383</subject><subject>631/535</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens, Bacterial - immunology</subject><subject>Antigens, CD1d - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Line</subject><subject>Galactosylceramides - immunology</subject><subject>Galactosylceramides - pharmacology</subject><subject>Glucuronates - immunology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infectious Diseases</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Molecular Sequence Data</subject><subject>Natural Killer T-Cells - immunology</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - immunology</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkU9u1DAUhyMEoqUgboC8Awml-F8mzgapqqAgVWJT2FqO85K-4rGD7bTqjjuw4RpchEP0JHjodADhjS2_z5_9_Kuqp4weMirUK4-HnDbsXrXPGt7VvGOr-7s1VXvVo5QuKGWyXcmH1R5nqzI6ul99PyIJ1lijvzQRjc_k088fjL4kZ8SCc6Ts4ASeRLAw5xDJACN6SMSQOcyLMxmDJ2Ek3uQlGkc-o3MQt8cTucJ8TgZMGb3NZHLXNjiccbgT33z9VtRh8vhbNMcwQ8wI6XH1YDQuwZPtfFB9fPvm7Phdffrh5P3x0WlthWC5BsVF13PoDedSjmowtqVmEHJkdiXZoEQnh6FnXBkjoe8a6JTpZc9aodpeWXFQvb71zku_hsGCz6UNPUdcm3itg0H9b8XjuZ7CpW4aJTuhiuD5VhDDlwVS1mtMm-aNh7AkrVrBuGxE84e0MaQUYdzdwqjexFjcehNjIZ_9_agdd5dbAV7cAqmU_ARRX4Ql-vJR_7l-AS6cq_U</recordid><startdate>20110612</startdate><enddate>20110612</enddate><creator>Uldrich, Adam P</creator><creator>Patel, Onisha</creator><creator>Cameron, Garth</creator><creator>Pellicci, Daniel G</creator><creator>Day, E Bridie</creator><creator>Sullivan, Lucy C</creator><creator>Kyparissoudis, Konstantinos</creator><creator>Kjer-Nielsen, Lars</creator><creator>Vivian, Julian P</creator><creator>Cao, Benjamin</creator><creator>Brooks, Andrew G</creator><creator>Williams, Spencer J</creator><creator>Illarionov, Petr</creator><creator>Besra, Gurdyal S</creator><creator>Turner, Stephen J</creator><creator>Porcelli, Steven A</creator><creator>McCluskey, James</creator><creator>Smyth, Mark J</creator><creator>Rossjohn, Jamie</creator><creator>Godfrey, Dale I</creator><general>Nature Publishing Group US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110612</creationdate><title>A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen–recognition properties</title><author>Uldrich, Adam P ; 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α
14-J
α
18 T cell antigen receptor α-chain. Godfrey and colleagues describe a population of CD1d-restricted natural killer T cells that express a previously unidentified canonical V
α
10-J
α
50 α-chain.
Type I natural killer T cells (NKT cells) are characterized by an invariant variable region 14–joining region 18 (V
α
14-J
α
18) T cell antigen receptor (TCR) α-chain and recognition of the glycolipid α-galactosylceramide (α-GalCer) restricted to the antigen-presenting molecule CD1d. Here we describe a population of α-GalCer-reactive NKT cells that expressed a canonical V
α
10-J
α
50 TCR α-chain, which showed a preference for α-glucosylceramide (α-GlcCer) and bacterial α-glucuronic acid–containing glycolipid antigens. Structurally, despite very limited TCRα sequence identity, the V
α
10 TCR–CD1d–α-GlcCer complex had a docking mode similar to that of type I TCR–CD1d–α-GalCer complexes, although differences at the antigen-binding interface accounted for the altered antigen specificity. Our findings provide new insight into the structural basis and evolution of glycolipid antigen recognition and have notable implications for the scope and immunological role of glycolipid-specific T cell responses.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>21666690</pmid><doi>10.1038/ni.2051</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1529-2908 |
| ispartof | Nature immunology, 2011-06, Vol.12 (7), p.616-623 |
| issn | 1529-2908 1529-2916 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5584938 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | 631/250/1619/554/383 631/535 Adjuvants, Immunologic - pharmacology Amino Acid Sequence Animals Antigens, Bacterial - immunology Antigens, CD1d - immunology Biomedical and Life Sciences Biomedicine Cell Line Galactosylceramides - immunology Galactosylceramides - pharmacology Glucuronates - immunology Humans Immunology Infectious Diseases Mice Mice, Mutant Strains Molecular Sequence Data Natural Killer T-Cells - immunology Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology |
| title | A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen–recognition properties |
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