Epac1, PDE4, and PKC protein expression and their association with AKAP95, Cx43, and cyclinD2/E1 in breast cancer tissues

Epac1, PDE4, and PKC protein expression and their association with AKAP95, Cx43, and cyclinD2/E1 in breast cancer tissues

Background This study was conducted to investigate the exchange protein directly activated by cAMP (Epac1), PDE4, and PKC expression in breast cancer tissues, and the correlation between these proteins and AKAP95, Cx43, cyclin D2, and cyclin E1. Methods PV‐9000 two‐step immunohistochemistry was used...

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Veröffentlicht in:Thoracic cancer 2017-09, Vol.8 (5), p.495-500
Hauptverfasser: Huang, Ping, Sun, Qian, Zhuang, Wenxin, Peng, Kuan, Wang, Dai, Yao, Youliang, Guo, Dongbei, Zhang, Lu, Shen, Chuhan, Sun, Mengyun, Tang, Chaoying, Teng, Bogang, Zhang, Yongxing
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Sprache:eng
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A Kinase Anchor Proteins - metabolism
Adult
Aged
Aged, 80 and over
AKAP95
Analysis
association analysis
Breast cancer
breast cancer tissue
Breast Neoplasms - metabolism
Connexin 43 - metabolism
Cyclic adenylic acid
Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism
Cyclin D2 - metabolism
Cyclin E - metabolism
Cyclins - metabolism
Epac1
Female
Gene Expression Regulation, Neoplastic
Guanine Nucleotide Exchange Factors - metabolism
Humans
Immunohistochemistry
Middle Aged
Oncogene Proteins - metabolism
Original
PDE4
Protein Kinase C - metabolism
Proteomics
Tumor proteins
Up-Regulation
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Zusammenfassung:Background This study was conducted to investigate the exchange protein directly activated by cAMP (Epac1), PDE4, and PKC expression in breast cancer tissues, and the correlation between these proteins and AKAP95, Cx43, cyclin D2, and cyclin E1. Methods PV‐9000 two‐step immunohistochemistry was used to analyze protein expression. Results The positive rate of Epac1 protein expression in breast cancer tissues (58%) was higher than in para‐carcinoma tissues (10%) (P  0.05). The positive expression rate of PDE4 was higher in the P53 protein positive group compared to the P53 negative group (P 
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.12475