Prognostic role of podocalyxin-like protein expression in various cancers: A systematic review and meta-analysis

Several studies were conducted to explore the prognostic significance of podocalyxin-like protein (PODXL) expression in various cancers, with contradictory. This study aims to summarize the prognostic significance of PODXL expression in cancers. PubMed, the Cochrane Library and Embase were completel...

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Veröffentlicht in:Oncotarget 2017-08, Vol.8 (32), p.52457-52464
Hauptverfasser: Wang, Jing, Zhao, Yongzhao, Qi, Ruizhao, Zhu, Xiaoning, Huang, Chenshen, Cheng, Sijin, Wang, Shengzhi, Qi, Xiaolong
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Sprache:eng
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Zusammenfassung:Several studies were conducted to explore the prognostic significance of podocalyxin-like protein (PODXL) expression in various cancers, with contradictory. This study aims to summarize the prognostic significance of PODXL expression in cancers. PubMed, the Cochrane Library and Embase were completely retrieved. The prospective or retrospective studies focusing on the prognostic role of PODXL expression in cancers were eligible. The endpoints were overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS).12 studies involving a total of 5,309 patients were identified. The results indicated that high PODXL expression was significantly associated with worse OS when compared to the low PODXL expression (HR=1.76, 95%CI=1.53-2.04, p
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.14199