CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia

RATIONALE:We hypothesized that cluster of differentiation 74 (CD74) downregulation on placental macrophages, leading to altered macrophage-trophoblast interaction, is involved in preeclampsia. OBJECTIVE:Preeclamptic pregnancies feature hypertension, proteinuria, and placental anomalies. Feto-placent...

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Veröffentlicht in:	Circulation research 2016-06, Vol.119 (1), p.55-68
Hauptverfasser:	Przybyl, Lukasz, Haase, Nadine, Golic, Michaela, Rugor, Julianna, Solano, Maria Emilia, Arck, Petra Clara, Gauster, Martin, Huppertz, Berthold, Emontzpohl, Christoph, Stoppe, Christian, Bernhagen, Jürgen, Leng, Lin, Bucala, Richard, Schulz, Herbert, Heuser, Arnd, Weedon-Fekjær, M Susanne, Johnsen, Guro M, Peetz, Dirk, Luft, Friedrich C, Staff, Anne Cathrine, Müller, Dominik N, Dechend, Ralf, Herse, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, B-Lymphocyte - genetics Antigens, Differentiation, B-Lymphocyte - metabolism Case-Control Studies Cell Adhesion Molecules - metabolism Cells, Cultured Chemokine CXCL5 - metabolism Cytochrome P-450 Enzyme System - metabolism Down-Regulation Female Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - metabolism Humans Interleukin-8 - metabolism Macrophages - metabolism Mice Mice, Inbred C57BL Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Pregnancy Syndecan-2 - metabolism Trophoblasts - cytology Trophoblasts - metabolism Tumor Necrosis Factor-alpha - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism
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Zusammenfassung:	RATIONALE:We hypothesized that cluster of differentiation 74 (CD74) downregulation on placental macrophages, leading to altered macrophage-trophoblast interaction, is involved in preeclampsia. OBJECTIVE:Preeclamptic pregnancies feature hypertension, proteinuria, and placental anomalies. Feto-placental macrophages regulate villous trophoblast differentiation during placental development. Disturbance of this well-balanced regulation can lead to pathological pregnancies. METHODS AND RESULTS:We performed whole-genome expression analysis of placental tissue. CD74 was one of the most downregulated genes in placentas from preeclamptic women. By reverse transcriptase-polymerase chain reaction, we confirmed this finding in early-onset (
ISSN:	0009-7330 1524-4571
DOI:	10.1161/CIRCRESAHA.116.308304