A comprehensive analysis of the association of common variants of ABCG2 with gout

A comprehensive analysis of the association of common variants of ABCG2 with gout

The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2...

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Veröffentlicht in:Scientific reports 2017-08, Vol.7 (1), p.9988-8, Article 9988
Hauptverfasser: Yu, Kuang-Hui, Chang, Pi-Yueh, Chang, Shih-Cheng, Wu-Chou, Yah-Huei, Wu, Li-An, Chen, Ding-Pin, Lo, Fu-Sung, Lu, Jang-Jih
Format: Artikel
Sprache:eng
Schlagworte:
45
45/43
631/208/205
692/4023/1670/3/2765/1528
Gout
Haplotypes
Humanities and Social Sciences
multidisciplinary
Polymorphism
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
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Zusammenfassung:The objective of the present study was to determine whether there was an association between single nucleotide polymorphisms (SNPs) in ABCG2 and gout. We recruited 333 participants including 210 patients with gout and 123 controls and genotyped 45 SNPs in both cohorts. We found that 24 SNPs in ABCG2 are susceptibility loci associated with gout. Haplotype analysis revealed five blocks across the ABCG2 locus were associated with an increased risk of gout with odds ratios (ORs) from 2.59–3.17 (all P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-10196-2