The Effect of Gene Alterations and Tyrosine Kinase Inhibition on Survival and Cause of Death in Patients with Adenocarcinoma of the Lung and Brain Metastases

Abstract Purpose Lung cancer remains the most common cause of both cancer mortality and brain metastases (BM). The purpose of this study was to assess the effect of gene alterations and tyrosine kinase inhibition (TKI) on median survival (MS) and cause of death (CoD) in patients with BM from lung ad...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2016-10, Vol.96 (2), p.406-413
Hauptverfasser:	Sperduto, Paul W., MD, MPP, FASTRO, Yang, T. Jonathan, MD, Beal, Kathryn, MD, Pan, Hubert, MD, Brown, Paul D., MD, Bangdiwala, Ananta, MS, Shanley, Ryan, MS, Yeh, Norman, MD, Gaspar, Laurie E., MD, MBA, FASTRO, Braunstein, Steve, MD, PhD, Sneed, Penny, MD, Boyle, John, MD, Kirkpatrick, John P., MD, PhD, Mak, Kimberley S., MD, Shih, Helen A., MD, Engelman, Alex, MD, Roberge, David, MD, Arvold, Nils D., MD, Alexander, Brian, MD, Awad, Mark M., MD, PhD, Contessa, Joseph, MD, Chiang, Veronica, MD, Hardie, John, MD, PhD, Ma, Daniel, MD, Lou, Emil, MD, PhD, Sperduto, William, BA, Mehta, Minesh P., MD, FASTRO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - secondary Aged Aged, 80 and over Anaplastic Lymphoma Kinase Antineoplastic Agents - therapeutic use BRAIN Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - secondary DEATH ErbB Receptors - genetics Female GENES Genetic Markers - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Hematology, Oncology and Palliative Medicine Humans Incidence INHIBITION Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - mortality LUNGS Male Middle Aged Mutation - genetics PATIENTS PHOSPHOTRANSFERASES Polymorphism, Single Nucleotide - genetics Prevalence Protein-Tyrosine Kinases - antagonists & inhibitors Radiology RADIOLOGY AND NUCLEAR MEDICINE Receptor Protein-Tyrosine Kinases - genetics Retrospective Studies Risk Factors Survival Rate TYROSINE United States - epidemiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Abstract Purpose Lung cancer remains the most common cause of both cancer mortality and brain metastases (BM). The purpose of this study was to assess the effect of gene alterations and tyrosine kinase inhibition (TKI) on median survival (MS) and cause of death (CoD) in patients with BM from lung adenocarcinoma (L-adeno). Methods A multi-institutional retrospective database of L-Adeno patients and newly diagnosed BM between 2006-2014 was created. Demographics, gene alterations, treatment, MS and CoD were analyzed. Treatment patterns and outcomes were compared to prior trials. Results Of 1521 L-adeno patients, 816 (54%) had known alteration status. Gene alteration rates were 29, 10, 26% for EGFR, ALK, KRAS, respectively. Time from primary diagnosis to BM for EGFR -/+ was 10/15 months (p=0.02) and for ALK -/+ was 10/20 (p
ISSN:	0360-3016 1879-355X
DOI:	10.1016/j.ijrobp.2016.06.006