Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation

With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Dev...

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Veröffentlicht in:CPT: pharmacometrics and systems pharmacology 2017-08, Vol.6 (8), p.496-498
Hauptverfasser: Ribba, B, Grimm, HP, Agoram, B, Davies, MR, Gadkar, K, Niederer, S, van Riel, N, Timmis, J, van der Graaf, PH
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Congresses as Topic
Drug Design
Drug Discovery - methods
Drug dosages
Humans
Hypotheses
Organisms
Parameter estimation
Pharmacology
Physiology
R&D
Research & development
Systems Biology - methods
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Zusammenfassung:With the increased interest in the application of quantitative systems pharmacology (QSP) models within medicine research and development, there is an increasing need to formalize model development and verification aspects. In February 2016, a workshop was held at Roche Pharma Research and Early Development to focus discussions on two critical methodological aspects of QSP model development: optimal structural granularity and parameter estimation. We here report in a perspective article a summary of presentations and discussions.
ISSN:2163-8306
2163-8306
DOI:10.1002/psp4.12206