A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity
The development of a strategy to stabilise the cubic phase of HfO 2 at lower temperatures is necessary for the emergence of unique properties that are not realised in the thermodynamically stable monoclinic phase. A very high temperature (>2600 °C) is required to produce the cubic phase of HfO 2...
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| creator | Kumar, Neeraj George, Blassan Plackal Adimuriyil Abrahamse, Heidi Parashar, Vyom Ray, Suprakas Sinha Ngila, Jane Catherine |
| description | The development of a strategy to stabilise the cubic phase of HfO
2
at lower temperatures is necessary for the emergence of unique properties that are not realised in the thermodynamically stable monoclinic phase. A very high temperature (>2600 °C) is required to produce the cubic phase of HfO
2
, whereas the monoclinic phase is stable at low temperature. Here, a novel rapid synthesis strategy was designed to develop highly crystalline, pure cubic-phase HfO
2
nanoparticles (size |
| doi_str_mv | 10.1038/s41598-017-07753-0 |
| format | Article |
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2
at lower temperatures is necessary for the emergence of unique properties that are not realised in the thermodynamically stable monoclinic phase. A very high temperature (>2600 °C) is required to produce the cubic phase of HfO
2
, whereas the monoclinic phase is stable at low temperature. Here, a novel rapid synthesis strategy was designed to develop highly crystalline, pure cubic-phase HfO
2
nanoparticles (size <10 nm) using microwave irradiation. Furthermore, the as-prepared nanoparticles were converted to different morphologies (spherical nanoparticles and nanoplates) without compromising the cubic phase by employing a post-hydrothermal treatment in the presence of surface modifiers. The cytotoxicities and proliferative profiles of the synthesised cubic HfO
2
nanostructures were investigated over the MCF-7 breast cancer cell line, along with caspase-3/7 activities. The low-temperature phase stabilisation was significantly attributed to surface imperfections (defects and deformations) induced in the crystal lattice by the desirable presence of Na
2
S·xH
2
O and NaOH. Our work provides unprecedented insight into the stabilisation of nanoscale cubic-phase HfO
2
in ambient environments; the method could be extended to other challenging phases of nanomaterials.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-07753-0</identifier><identifier>PMID: 28839143</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14/34 ; 140/133 ; 140/146 ; 631/67/1347 ; 639/301/357/551 ; Breast cancer ; Caspase ; Caspase-3 ; Cytotoxicity ; Humanities and Social Sciences ; multidisciplinary ; Nanoparticles ; Nanotechnology ; Science ; Science (multidisciplinary) ; Temperature ; Temperature effects ; Temperature requirements</subject><ispartof>Scientific reports, 2017-08, Vol.7 (1), p.1-14, Article 9351</ispartof><rights>The Author(s) 2017</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-adb2f7819a89cc525544b36997c6869d35d502f25f9acad756b32e88aeaed5473</citedby><cites>FETCH-LOGICAL-c451t-adb2f7819a89cc525544b36997c6869d35d502f25f9acad756b32e88aeaed5473</cites><orcidid>0000-0001-5395-4850</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570928/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570928/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids></links><search><creatorcontrib>Kumar, Neeraj</creatorcontrib><creatorcontrib>George, Blassan Plackal Adimuriyil</creatorcontrib><creatorcontrib>Abrahamse, Heidi</creatorcontrib><creatorcontrib>Parashar, Vyom</creatorcontrib><creatorcontrib>Ray, Suprakas Sinha</creatorcontrib><creatorcontrib>Ngila, Jane Catherine</creatorcontrib><title>A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><description>The development of a strategy to stabilise the cubic phase of HfO
2
at lower temperatures is necessary for the emergence of unique properties that are not realised in the thermodynamically stable monoclinic phase. A very high temperature (>2600 °C) is required to produce the cubic phase of HfO
2
, whereas the monoclinic phase is stable at low temperature. Here, a novel rapid synthesis strategy was designed to develop highly crystalline, pure cubic-phase HfO
2
nanoparticles (size <10 nm) using microwave irradiation. Furthermore, the as-prepared nanoparticles were converted to different morphologies (spherical nanoparticles and nanoplates) without compromising the cubic phase by employing a post-hydrothermal treatment in the presence of surface modifiers. The cytotoxicities and proliferative profiles of the synthesised cubic HfO
2
nanostructures were investigated over the MCF-7 breast cancer cell line, along with caspase-3/7 activities. The low-temperature phase stabilisation was significantly attributed to surface imperfections (defects and deformations) induced in the crystal lattice by the desirable presence of Na
2
S·xH
2
O and NaOH. Our work provides unprecedented insight into the stabilisation of nanoscale cubic-phase HfO
2
in ambient environments; the method could be extended to other challenging phases of nanomaterials.</description><subject>14/34</subject><subject>140/133</subject><subject>140/146</subject><subject>631/67/1347</subject><subject>639/301/357/551</subject><subject>Breast cancer</subject><subject>Caspase</subject><subject>Caspase-3</subject><subject>Cytotoxicity</subject><subject>Humanities and Social Sciences</subject><subject>multidisciplinary</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Temperature</subject><subject>Temperature effects</subject><subject>Temperature requirements</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kV9LHTEQxUOxVLF-gT4F-tKXrfk3m-SlIGKrIPjSPodsNuuN7E22SVa9377RK2ILnZcZmN85zHAQ-kTJV0q4Oi2CglYdobIjUgLvyDt0xIiAjnHGDt7Mh-iklDvSCpgWVH9Ah0wprqngR8ie4Zju_YztsuRk3QbXhOf00FW_XXy2dc0el12sG19CwWnCbh2Cw5fTDcPRxlRqXt0TVbCNI25cyNjtaqrpMbhQdx_R-8nOxZ-89GP06_vFz_PL7vrmx9X52XXnBNDa2XFgk1RUW6WdAwYgxMB7raXrVa9HDiMQNjGYtHV2lNAPnHmlrLd-BCH5Mfq2913WYetH52PNdjZLDlubdybZYP7exLAxt-neAEiimWoGX14Mcvq9-lLNNhTn59lGn9ZiqOZMCSCib-jnf9C7tObY3msUSKZ7AaxRbE-5nErJfno9hhLzFKLZh2haiOY5REOaiO9FpcHx1uc31v9X_QFEHZ92</recordid><startdate>20170824</startdate><enddate>20170824</enddate><creator>Kumar, Neeraj</creator><creator>George, Blassan Plackal Adimuriyil</creator><creator>Abrahamse, Heidi</creator><creator>Parashar, Vyom</creator><creator>Ray, Suprakas Sinha</creator><creator>Ngila, Jane Catherine</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5395-4850</orcidid></search><sort><creationdate>20170824</creationdate><title>A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity</title><author>Kumar, Neeraj ; 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2
at lower temperatures is necessary for the emergence of unique properties that are not realised in the thermodynamically stable monoclinic phase. A very high temperature (>2600 °C) is required to produce the cubic phase of HfO
2
, whereas the monoclinic phase is stable at low temperature. Here, a novel rapid synthesis strategy was designed to develop highly crystalline, pure cubic-phase HfO
2
nanoparticles (size <10 nm) using microwave irradiation. Furthermore, the as-prepared nanoparticles were converted to different morphologies (spherical nanoparticles and nanoplates) without compromising the cubic phase by employing a post-hydrothermal treatment in the presence of surface modifiers. The cytotoxicities and proliferative profiles of the synthesised cubic HfO
2
nanostructures were investigated over the MCF-7 breast cancer cell line, along with caspase-3/7 activities. The low-temperature phase stabilisation was significantly attributed to surface imperfections (defects and deformations) induced in the crystal lattice by the desirable presence of Na
2
S·xH
2
O and NaOH. Our work provides unprecedented insight into the stabilisation of nanoscale cubic-phase HfO
2
in ambient environments; the method could be extended to other challenging phases of nanomaterials.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28839143</pmid><doi>10.1038/s41598-017-07753-0</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-5395-4850</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 14/34 140/133 140/146 631/67/1347 639/301/357/551 Breast cancer Caspase Caspase-3 Cytotoxicity Humanities and Social Sciences multidisciplinary Nanoparticles Nanotechnology Science Science (multidisciplinary) Temperature Temperature effects Temperature requirements |
| title | A novel approach to low-temperature synthesis of cubic HfO2 nanostructures and their cytotoxicity |
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