Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants
Radiofrequency ablation has emerged as a minimally invasive option for liver cancer treatment, but local tumor recurrence is common. To eliminate residual tumor cells in the ablated tumor, biodegradable polymer millirods have been designed for local drug (e.g., doxorubicin) delivery. A limitation of...
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| Veröffentlicht in: | Medical & biological engineering & computing 2008-10, Vol.46 (10), p.1039-1049 |
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| creator | Weinberg, Brent D. Patel, Ravi B. Wu, Hanping Blanco, Elvin Barnett, Carlton C. Exner, Agata A. Saidel, Gerald M. Gao, Jinming |
| description | Radiofrequency ablation has emerged as a minimally invasive option for liver cancer treatment, but local tumor recurrence is common. To eliminate residual tumor cells in the ablated tumor, biodegradable polymer millirods have been designed for local drug (e.g., doxorubicin) delivery. A limitation of this method has been the extent of drug penetration into the tumor ( |
| doi_str_mv | 10.1007/s11517-008-0354-7 |
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To eliminate residual tumor cells in the ablated tumor, biodegradable polymer millirods have been designed for local drug (e.g., doxorubicin) delivery. A limitation of this method has been the extent of drug penetration into the tumor (<5 mm), especially in the peripheral tumor rim where thermal ablation is less effective. To provide drug concentration above the therapeutic level as needed throughout a large tumor, implant strategies with multiple millirods were devised using a computational model. This dynamic, 3-D mass balance model of drug distribution in tissue was used to simulate the consequences of various numbers of implants in different locations. Experimental testing of model predictions was performed in a rabbit VX2 carcinoma model. This study demonstrates the value of multiple implants to provide therapeutic drug levels in large ablated tumors.</description><identifier>ISSN: 0140-0118</identifier><identifier>EISSN: 1741-0444</identifier><identifier>DOI: 10.1007/s11517-008-0354-7</identifier><identifier>PMID: 18523817</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Ablation ; Absorbable Implants ; Animals ; Antineoplastic Agents - administration & dosage ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Brain cancer ; Cancer therapies ; Catheter Ablation - methods ; Chemotherapy ; Combined Modality Therapy ; Computer Applications ; Design ; Drug Implants ; Human Physiology ; Imaging ; Liver cancer ; Liver Neoplasms - drug therapy ; Liver Neoplasms - surgery ; Mathematical models ; Models, Biological ; Original Article ; Polymers ; Prostate ; Rabbits ; Radiation therapy ; Radiology ; Simulation ; Studies ; Transplants & implants ; Tumors</subject><ispartof>Medical & biological engineering & computing, 2008-10, Vol.46 (10), p.1039-1049</ispartof><rights>International Federation for Medical and Biological Engineering 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-ca44bb04224c90ca5c933eafba3280956469ec75abc622ef244ae91e843c97d53</citedby><cites>FETCH-LOGICAL-c529t-ca44bb04224c90ca5c933eafba3280956469ec75abc622ef244ae91e843c97d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11517-008-0354-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11517-008-0354-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18523817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weinberg, Brent D.</creatorcontrib><creatorcontrib>Patel, Ravi B.</creatorcontrib><creatorcontrib>Wu, Hanping</creatorcontrib><creatorcontrib>Blanco, Elvin</creatorcontrib><creatorcontrib>Barnett, Carlton C.</creatorcontrib><creatorcontrib>Exner, Agata A.</creatorcontrib><creatorcontrib>Saidel, Gerald M.</creatorcontrib><creatorcontrib>Gao, Jinming</creatorcontrib><title>Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants</title><title>Medical & biological engineering & computing</title><addtitle>Med Biol Eng Comput</addtitle><addtitle>Med Biol Eng Comput</addtitle><description>Radiofrequency ablation has emerged as a minimally invasive option for liver cancer treatment, but local tumor recurrence is common. To eliminate residual tumor cells in the ablated tumor, biodegradable polymer millirods have been designed for local drug (e.g., doxorubicin) delivery. A limitation of this method has been the extent of drug penetration into the tumor (<5 mm), especially in the peripheral tumor rim where thermal ablation is less effective. To provide drug concentration above the therapeutic level as needed throughout a large tumor, implant strategies with multiple millirods were devised using a computational model. This dynamic, 3-D mass balance model of drug distribution in tissue was used to simulate the consequences of various numbers of implants in different locations. Experimental testing of model predictions was performed in a rabbit VX2 carcinoma model. This study demonstrates the value of multiple implants to provide therapeutic drug levels in large ablated tumors.</description><subject>Ablation</subject><subject>Absorbable Implants</subject><subject>Animals</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Brain cancer</subject><subject>Cancer therapies</subject><subject>Catheter Ablation - methods</subject><subject>Chemotherapy</subject><subject>Combined Modality Therapy</subject><subject>Computer Applications</subject><subject>Design</subject><subject>Drug Implants</subject><subject>Human Physiology</subject><subject>Imaging</subject><subject>Liver cancer</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - surgery</subject><subject>Mathematical models</subject><subject>Models, Biological</subject><subject>Original 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polymer implants</atitle><jtitle>Medical & biological engineering & computing</jtitle><stitle>Med Biol Eng Comput</stitle><addtitle>Med Biol Eng Comput</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>46</volume><issue>10</issue><spage>1039</spage><epage>1049</epage><pages>1039-1049</pages><issn>0140-0118</issn><eissn>1741-0444</eissn><abstract>Radiofrequency ablation has emerged as a minimally invasive option for liver cancer treatment, but local tumor recurrence is common. To eliminate residual tumor cells in the ablated tumor, biodegradable polymer millirods have been designed for local drug (e.g., doxorubicin) delivery. A limitation of this method has been the extent of drug penetration into the tumor (<5 mm), especially in the peripheral tumor rim where thermal ablation is less effective. To provide drug concentration above the therapeutic level as needed throughout a large tumor, implant strategies with multiple millirods were devised using a computational model. This dynamic, 3-D mass balance model of drug distribution in tissue was used to simulate the consequences of various numbers of implants in different locations. Experimental testing of model predictions was performed in a rabbit VX2 carcinoma model. This study demonstrates the value of multiple implants to provide therapeutic drug levels in large ablated tumors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18523817</pmid><doi>10.1007/s11517-008-0354-7</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ablation Absorbable Implants Animals Antineoplastic Agents - administration & dosage Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Brain cancer Cancer therapies Catheter Ablation - methods Chemotherapy Combined Modality Therapy Computer Applications Design Drug Implants Human Physiology Imaging Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - surgery Mathematical models Models, Biological Original Article Polymers Prostate Rabbits Radiation therapy Radiology Simulation Studies Transplants & implants Tumors |
| title | Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants |
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