Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants

Model simulation and experimental validation of intratumoral chemotherapy using multiple polymer implants

Radiofrequency ablation has emerged as a minimally invasive option for liver cancer treatment, but local tumor recurrence is common. To eliminate residual tumor cells in the ablated tumor, biodegradable polymer millirods have been designed for local drug (e.g., doxorubicin) delivery. A limitation of...

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Veröffentlicht in:Medical & biological engineering & computing 2008-10, Vol.46 (10), p.1039-1049
Hauptverfasser: Weinberg, Brent D., Patel, Ravi B., Wu, Hanping, Blanco, Elvin, Barnett, Carlton C., Exner, Agata A., Saidel, Gerald M., Gao, Jinming
Format: Artikel
Sprache:eng
Schlagworte:
Ablation
Absorbable Implants
Animals
Antineoplastic Agents - administration & dosage
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Biomedicine
Brain cancer
Cancer therapies
Catheter Ablation - methods
Chemotherapy
Combined Modality Therapy
Computer Applications
Design
Drug Implants
Human Physiology
Imaging
Liver cancer
Liver Neoplasms - drug therapy
Liver Neoplasms - surgery
Mathematical models
Models, Biological
Original Article
Polymers
Prostate
Rabbits
Radiation therapy
Radiology
Simulation
Studies
Transplants & implants
Tumors
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Zusammenfassung:Radiofrequency ablation has emerged as a minimally invasive option for liver cancer treatment, but local tumor recurrence is common. To eliminate residual tumor cells in the ablated tumor, biodegradable polymer millirods have been designed for local drug (e.g., doxorubicin) delivery. A limitation of this method has been the extent of drug penetration into the tumor (
ISSN:0140-0118
1741-0444
DOI:10.1007/s11517-008-0354-7