Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites

Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites

This study sought to assess the pharmacokinetic (PK) changes of caffeine and its CYP1A2 metabolites across the 3 trimesters of pregnancy. A prospective, multicenter PK study was conducted among 59 pregnant women (93.2% white) who were studied once during a trimester. One beverage with 30‐95 mg caffe...

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Veröffentlicht in:Journal of clinical pharmacology 2016-05, Vol.56 (5), p.590-596
Hauptverfasser: Yu, Tian, Campbell, Sarah C., Stockmann, Chris, Tak, Casey, Schoen, Katherine, Clark, Erin A. S., Varner, Michael W., Spigarelli, Michael G., Sherwin, Catherine M. T.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Caffeine
Caffeine - blood
Caffeine - pharmacokinetics
Caffeine - urine
Cytochrome P-450 CYP1A2 - metabolism
Female
Humans
Metabolism
Metabolites
pharmacokinetics
Pregnancy
Pregnancy - blood
Pregnancy - metabolism
Pregnancy - urine
Pregnancy Trimesters - blood
Pregnancy Trimesters - metabolism
Pregnancy Trimesters - urine
Theobromine - blood
Theophylline - blood
Urine
Young Adult
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Zusammenfassung:This study sought to assess the pharmacokinetic (PK) changes of caffeine and its CYP1A2 metabolites across the 3 trimesters of pregnancy. A prospective, multicenter PK study was conducted among 59 pregnant women (93.2% white) who were studied once during a trimester. One beverage with 30‐95 mg caffeine was consumed, and a blood/urine sample was collected within 1 hour postingestion. Concentrations of caffeine and its primary metabolites were quantified from serum and urine by LC‐MS/MS. There was a significant increase in dose‐normalized caffeine serum and urine concentrations between the first and third trimesters (P 
ISSN:0091-2700
1552-4604
DOI:10.1002/jcph.632