The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit

Use of the ResearchKit platform to track symptoms of a large cohort of asthma sufferers over time demonstrates the pros and cons of mobile health applications in large-scale observational studies. The feasibility of using mobile health applications to conduct observational clinical studies requires...

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Veröffentlicht in:Nature biotechnology 2017-04, Vol.35 (4), p.354-362
Hauptverfasser: Chan, Yu-Feng Yvonne, Wang, Pei, Rogers, Linda, Tignor, Nicole, Zweig, Micol, Hershman, Steven G, Genes, Nicholas, Scott, Erick R, Krock, Eric, Badgeley, Marcus, Edgar, Ron, Violante, Samantha, Wright, Rosalind, Powell, Charles A, Dudley, Joel T, Schadt, Eric E
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Sprache:eng
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Zusammenfassung:Use of the ResearchKit platform to track symptoms of a large cohort of asthma sufferers over time demonstrates the pros and cons of mobile health applications in large-scale observational studies. The feasibility of using mobile health applications to conduct observational clinical studies requires rigorous validation. Here, we report initial findings from the Asthma Mobile Health Study, a research study, including recruitment, consent, and enrollment, conducted entirely remotely by smartphone. We achieved secure bidirectional data flow between investigators and 7,593 participants from across the United States, including many with severe asthma. Our platform enabled prospective collection of longitudinal, multidimensional data (e.g., surveys, devices, geolocation, and air quality) in a subset of users over the 6-month study period. Consistent trending and correlation of interrelated variables support the quality of data obtained via this method. We detected increased reporting of asthma symptoms in regions affected by heat, pollen, and wildfires. Potential challenges with this technology include selection bias, low retention rates, reporting bias, and data security. These issues require attention to realize the full potential of mobile platforms in research and patient care.
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt.3826