Targeting T cell metabolism to regulate T cell activation, differentiation and function in disease

Highlights • Metabolic reprogramming is intimately linked to T cell activation. • Different T cell subsets have different metabolic demands. • Selectivity of targeting metabolism is achieved based on cellular demand. • Targeting metabolism can both inhibit and enhance T cell function. • Targeting me...

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Veröffentlicht in:	Current opinion in immunology 2017-06, Vol.46, p.82-88
Hauptverfasser:	Patel, Chirag H, Powell, Jonathan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Amino Acids - metabolism Animals Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmunity - drug effects Autoimmunity - immunology Cell Differentiation - drug effects Cell Differentiation - immunology Cellular Microenvironment - drug effects Cellular Microenvironment - immunology Energy Metabolism - drug effects Glycolysis - drug effects Graft Rejection - drug therapy Graft Rejection - immunology Graft Rejection - metabolism Humans Immunotherapy Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Mitochondria - drug effects Mitochondria - metabolism Molecular Targeted Therapy Signal Transduction - drug effects T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism TOR Serine-Threonine Kinases - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Metabolic reprogramming is intimately linked to T cell activation. • Different T cell subsets have different metabolic demands. • Selectivity of targeting metabolism is achieved based on cellular demand. • Targeting metabolism can both inhibit and enhance T cell function. • Targeting metabolism represents a novel means to treat autoimmunity, transplant rejection and enhance immunotherapy.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2017.04.006