Coronavirus mRNA synthesis involves fusion of non‐contiguous sequences

Coronavirus mRNA synthesis involves fusion of non‐contiguous sequences

Positive‐stranded genomic RNA of coronavirus MHV and its six subgenomic mRNAs are synthesized in the cytoplasm of the host cell. The mRNAs are composed of leader and body sequences which are non‐contiguous on the genome and are fused together in the cytoplasm by a mechanism which appears to involve...

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Veröffentlicht in:The EMBO journal 1983, Vol.2 (10), p.1839-1844
Hauptverfasser: Spaan, W., Delius, H., Skinner, M., Armstrong, J., Rottier, P., Smeekens, S., Zeijst, B.A., Siddell, S.G.
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Biological and medical sciences
Coronaviridae - genetics
DNA - analysis
DNA - metabolism
Fundamental and applied biological sciences. Psychology
Genes, Viral
Genetics
Microbiology
Microscopy, Electron
Nucleic Acid Hybridization
RNA, Messenger - genetics
RNA, Viral - genetics
RNA-Directed DNA Polymerase
Virology
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Beschreibung
Zusammenfassung:Positive‐stranded genomic RNA of coronavirus MHV and its six subgenomic mRNAs are synthesized in the cytoplasm of the host cell. The mRNAs are composed of leader and body sequences which are non‐contiguous on the genome and are fused together in the cytoplasm by a mechanism which appears to involve an unusual and specific ‘polymerase jumping’ event.
ISSN:0261-4189
1460-2075
DOI:10.1002/j.1460-2075.1983.tb01667.x