Targeting Hsp70: A possible therapy for cancer

Highlights • Hsp70 is the most ancient anti-stress defensive system that promotes tumor cell survival by interacting at several points in apoptotic signaling pathway(s). • Interaction on different apoptotic pathways, immunological, and immunotherapeutic impacts of Hsp70 in cancer cell survival are s...

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Veröffentlicht in:	Cancer letters 2016-04, Vol.374 (1), p.156-166
Hauptverfasser:	Kumar, Sanjay, Stokes, James, Singh, Udai P, Scissum Gunn, Karyn, Acharya, Arbind, Manne, Upender, Mishra, Manoj
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cancer therapeutics Cancer therapies Cell growth Clinical trials Cytochrome Endoplasmic reticulum Gastric cancer Gene Knockdown Techniques Growth factors Heat shock proteins Hematology, Oncology and Palliative Medicine Homeostasis Hsp70 HSP70 Heat-Shock Proteins - antagonists & inhibitors HSP70 Heat-Shock Proteins - biosynthesis HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - immunology Humans Immunogenicity Kinases Medical prognosis Mitochondria Molecular Targeted Therapy Molecular weight Neoplasms - genetics Neoplasms - immunology Neoplasms - therapy Peptides Prostate cancer Protein folding
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Zusammenfassung:	Highlights • Hsp70 is the most ancient anti-stress defensive system that promotes tumor cell survival by interacting at several points in apoptotic signaling pathway(s). • Interaction on different apoptotic pathways, immunological, and immunotherapeutic impacts of Hsp70 in cancer cell survival are summarized. • Advance strategies to target Hsp70 are discussed and future directions are proposed. Hsp70 can be used as an immunotherapeutic drug because its potent adjuvant nature induces cancer autoimmunity.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.01.056