Early growth faltering in post-institutionalized youth and later anthropometric and pubertal development
Background Early-life adversity that increases the risk of growth stunting is hypothesized to increase the risk of obesity and, in girls, early-onset puberty. This hypothesis was tested in children adopted from orphanages. Methods Post-institutionalized (PI) youth were compared with youth reared in...
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| Veröffentlicht in: | Pediatric research 2017-08, Vol.82 (2), p.278-284 |
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| creator | Reid, Brie M Miller, Bradley S Dorn, Lorah D Desjardins, Christopher Donzella, Bonny Gunnar, Megan |
| description | Background
Early-life adversity that increases the risk of growth stunting is hypothesized to increase the risk of obesity and, in girls, early-onset puberty. This hypothesis was tested in children adopted from orphanages.
Methods
Post-institutionalized (PI) youth were compared with youth reared in comparable families (non-adopted; NA) on height, weight, pubertal stage, and fat mass (127 PI, 80 female; 156 NA, 85 female, aged 7–14 years). Anthropometric findings at adoption were obtained from first US clinic visits.
Results
Overall, 25% of PI youth were height-stunted ( |
| doi_str_mv | 10.1038/pr.2017.35 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5552432</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1866295860</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-1920b45efd355be16342da1f1fad47dd25e73bcc4551ccf5e0fe365a515b52693</originalsourceid><addsrcrecordid>eNplkVuLFDEQhYMo7rj64g-QBl9E6TG36suLIMt6gQVf9Dmkk-qZLOlOm6RXxl9vxlmXVZ9Sob46dahDyHNGt4yK7u0St5yydivgAdkwELSmUrYPyYZSwWrR990ZeZLSNaVMQicfkzPesbZMthuyv9TRH6pdDD_yvhq1zxjdvKvcXC0h5drNKbu8Zhdm7d1PtNUhrIXUs628LnCp8j6GJUyYozO_G8s6YMzaVxZv0Idlwjk_JY-KesJnt-85-fbh8uvFp_rqy8fPF--vagO0yzXrOR0k4GgFwICsEZJbzUY2aitbazlgKwZjJAAzZgSkI4oGNDAYgDe9OCfvTrrFxITWlNVRe7VEN-l4UEE79Xdndnu1CzcKALgUvAi8uhWI4fuKKavJJYPe6xnDmhTrmob30DW0oC__Qa_DGsuhCtXztljsoCnU6xNlYkgp4nhnhlF1DLD81TFAJaDAL-7bv0P_JFaANycgLcegMN7b-b_cL0X_p-Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1927551856</pqid></control><display><type>article</type><title>Early growth faltering in post-institutionalized youth and later anthropometric and pubertal development</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>SpringerLink Journals - AutoHoldings</source><creator>Reid, Brie M ; Miller, Bradley S ; Dorn, Lorah D ; Desjardins, Christopher ; Donzella, Bonny ; Gunnar, Megan</creator><creatorcontrib>Reid, Brie M ; Miller, Bradley S ; Dorn, Lorah D ; Desjardins, Christopher ; Donzella, Bonny ; Gunnar, Megan</creatorcontrib><description>Background
Early-life adversity that increases the risk of growth stunting is hypothesized to increase the risk of obesity and, in girls, early-onset puberty. This hypothesis was tested in children adopted from orphanages.
Methods
Post-institutionalized (PI) youth were compared with youth reared in comparable families (non-adopted; NA) on height, weight, pubertal stage, and fat mass (127 PI, 80 female; 156 NA, 85 female, aged 7–14 years). Anthropometric findings at adoption were obtained from first US clinic visits.
Results
Overall, 25% of PI youth were height-stunted (<3rd percentile) at adoption. Years post adoption, PI youth had lower BMI-for-age (
P
=0.004), height-for-age (
P
<0.001), and less body fat (
P
<0.001) than NA youth had, but they did not differ by sex. Pubertal status did not differ by group or sex. The anthropometric findings held when the stunted-at-adoption subset was examined; they were also less likely to be in central puberty than other PI youth.
Conclusion
Early deprived orphanage care increases the risk of growth stunting but not obesity in children adopted into US families, and it does not independently contribute to early-onset puberty for PI girls. The role of the environment following early adversity may modify the impact of early adverse care.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2017.35</identifier><identifier>PMID: 28170387</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/699/2743/1530 ; 692/699/2743/393 ; 692/700/1720/3187 ; 692/700/1750 ; Adolescent ; Adoption ; Anthropometry ; Body measurements ; Child ; clinical-investigation ; Female ; Growth ; Humans ; Institutionalization ; Male ; Medicine ; Medicine & Public Health ; Orphanages ; Pediatric Surgery ; Pediatrics ; Physical growth ; Puberty</subject><ispartof>Pediatric research, 2017-08, Vol.82 (2), p.278-284</ispartof><rights>International Pediatric Research Foundation, Inc. 2017</rights><rights>Copyright Nature Publishing Group Aug 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-1920b45efd355be16342da1f1fad47dd25e73bcc4551ccf5e0fe365a515b52693</citedby><cites>FETCH-LOGICAL-c508t-1920b45efd355be16342da1f1fad47dd25e73bcc4551ccf5e0fe365a515b52693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/pr.2017.35$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/pr.2017.35$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27915,27916,41479,42548,51310</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28170387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reid, Brie M</creatorcontrib><creatorcontrib>Miller, Bradley S</creatorcontrib><creatorcontrib>Dorn, Lorah D</creatorcontrib><creatorcontrib>Desjardins, Christopher</creatorcontrib><creatorcontrib>Donzella, Bonny</creatorcontrib><creatorcontrib>Gunnar, Megan</creatorcontrib><title>Early growth faltering in post-institutionalized youth and later anthropometric and pubertal development</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background
Early-life adversity that increases the risk of growth stunting is hypothesized to increase the risk of obesity and, in girls, early-onset puberty. This hypothesis was tested in children adopted from orphanages.
Methods
Post-institutionalized (PI) youth were compared with youth reared in comparable families (non-adopted; NA) on height, weight, pubertal stage, and fat mass (127 PI, 80 female; 156 NA, 85 female, aged 7–14 years). Anthropometric findings at adoption were obtained from first US clinic visits.
Results
Overall, 25% of PI youth were height-stunted (<3rd percentile) at adoption. Years post adoption, PI youth had lower BMI-for-age (
P
=0.004), height-for-age (
P
<0.001), and less body fat (
P
<0.001) than NA youth had, but they did not differ by sex. Pubertal status did not differ by group or sex. The anthropometric findings held when the stunted-at-adoption subset was examined; they were also less likely to be in central puberty than other PI youth.
Conclusion
Early deprived orphanage care increases the risk of growth stunting but not obesity in children adopted into US families, and it does not independently contribute to early-onset puberty for PI girls. The role of the environment following early adversity may modify the impact of early adverse care.</description><subject>692/699/2743/1530</subject><subject>692/699/2743/393</subject><subject>692/700/1720/3187</subject><subject>692/700/1750</subject><subject>Adolescent</subject><subject>Adoption</subject><subject>Anthropometry</subject><subject>Body measurements</subject><subject>Child</subject><subject>clinical-investigation</subject><subject>Female</subject><subject>Growth</subject><subject>Humans</subject><subject>Institutionalization</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Orphanages</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Physical growth</subject><subject>Puberty</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNplkVuLFDEQhYMo7rj64g-QBl9E6TG36suLIMt6gQVf9Dmkk-qZLOlOm6RXxl9vxlmXVZ9Sob46dahDyHNGt4yK7u0St5yydivgAdkwELSmUrYPyYZSwWrR990ZeZLSNaVMQicfkzPesbZMthuyv9TRH6pdDD_yvhq1zxjdvKvcXC0h5drNKbu8Zhdm7d1PtNUhrIXUs628LnCp8j6GJUyYozO_G8s6YMzaVxZv0Idlwjk_JY-KesJnt-85-fbh8uvFp_rqy8fPF--vagO0yzXrOR0k4GgFwICsEZJbzUY2aitbazlgKwZjJAAzZgSkI4oGNDAYgDe9OCfvTrrFxITWlNVRe7VEN-l4UEE79Xdndnu1CzcKALgUvAi8uhWI4fuKKavJJYPe6xnDmhTrmob30DW0oC__Qa_DGsuhCtXztljsoCnU6xNlYkgp4nhnhlF1DLD81TFAJaDAL-7bv0P_JFaANycgLcegMN7b-b_cL0X_p-Q</recordid><startdate>20170801</startdate><enddate>20170801</enddate><creator>Reid, Brie M</creator><creator>Miller, Bradley S</creator><creator>Dorn, Lorah D</creator><creator>Desjardins, Christopher</creator><creator>Donzella, Bonny</creator><creator>Gunnar, Megan</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170801</creationdate><title>Early growth faltering in post-institutionalized youth and later anthropometric and pubertal development</title><author>Reid, Brie M ; Miller, Bradley S ; Dorn, Lorah D ; Desjardins, Christopher ; Donzella, Bonny ; Gunnar, Megan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-1920b45efd355be16342da1f1fad47dd25e73bcc4551ccf5e0fe365a515b52693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>692/699/2743/1530</topic><topic>692/699/2743/393</topic><topic>692/700/1720/3187</topic><topic>692/700/1750</topic><topic>Adolescent</topic><topic>Adoption</topic><topic>Anthropometry</topic><topic>Body measurements</topic><topic>Child</topic><topic>clinical-investigation</topic><topic>Female</topic><topic>Growth</topic><topic>Humans</topic><topic>Institutionalization</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Orphanages</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Physical growth</topic><topic>Puberty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reid, Brie M</creatorcontrib><creatorcontrib>Miller, Bradley S</creatorcontrib><creatorcontrib>Dorn, Lorah D</creatorcontrib><creatorcontrib>Desjardins, Christopher</creatorcontrib><creatorcontrib>Donzella, Bonny</creatorcontrib><creatorcontrib>Gunnar, Megan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reid, Brie M</au><au>Miller, Bradley S</au><au>Dorn, Lorah D</au><au>Desjardins, Christopher</au><au>Donzella, Bonny</au><au>Gunnar, Megan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early growth faltering in post-institutionalized youth and later anthropometric and pubertal development</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2017-08-01</date><risdate>2017</risdate><volume>82</volume><issue>2</issue><spage>278</spage><epage>284</epage><pages>278-284</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><abstract>Background
Early-life adversity that increases the risk of growth stunting is hypothesized to increase the risk of obesity and, in girls, early-onset puberty. This hypothesis was tested in children adopted from orphanages.
Methods
Post-institutionalized (PI) youth were compared with youth reared in comparable families (non-adopted; NA) on height, weight, pubertal stage, and fat mass (127 PI, 80 female; 156 NA, 85 female, aged 7–14 years). Anthropometric findings at adoption were obtained from first US clinic visits.
Results
Overall, 25% of PI youth were height-stunted (<3rd percentile) at adoption. Years post adoption, PI youth had lower BMI-for-age (
P
=0.004), height-for-age (
P
<0.001), and less body fat (
P
<0.001) than NA youth had, but they did not differ by sex. Pubertal status did not differ by group or sex. The anthropometric findings held when the stunted-at-adoption subset was examined; they were also less likely to be in central puberty than other PI youth.
Conclusion
Early deprived orphanage care increases the risk of growth stunting but not obesity in children adopted into US families, and it does not independently contribute to early-onset puberty for PI girls. The role of the environment following early adversity may modify the impact of early adverse care.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>28170387</pmid><doi>10.1038/pr.2017.35</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; SpringerLink Journals - AutoHoldings |
| subjects | 692/699/2743/1530 692/699/2743/393 692/700/1720/3187 692/700/1750 Adolescent Adoption Anthropometry Body measurements Child clinical-investigation Female Growth Humans Institutionalization Male Medicine Medicine & Public Health Orphanages Pediatric Surgery Pediatrics Physical growth Puberty |
| title | Early growth faltering in post-institutionalized youth and later anthropometric and pubertal development |
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