Reduced ventilation–perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium‐68 V/Q photon emission tomography/computed tomography

Endobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV1). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium‐68 ventilation–perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT) is a novel imaging modality with advantages in spatial resolution, quantitation, and speed over conventional V/Q scintigraphy. We report a pilot case in which V/Q‐PET/CT demonstrated discordant findings compared with quantitative CT analysis, and directed left lower lobe EBV placement. The patient experienced a significant improvement in 6‐min walk distance (6MWD) without change in spirometry. Post‐EBV V/Q‐PET/CT demonstrated a marked decrease in unmatched (detrimental) V/Q areas and improvement in overall V/Q matching on post‐EBV V/Q‐PET/CT. These preliminary novel findings suggest that EBVs improve V/Q matching and may explain the observed functional improvements. Endobronchial valves (EBVs) are increasingly used in severe emphysema. Using Gallium‐68 ventilation–perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT), we report a pilot case in which PET/CT findings were discordant to standard quantitative CT analysis. We deployed valves in a lobe where benefit was not predicted with standard quantitative CT, and found significant clinical improvement and improved V/Q matching on repeat imaging.