Layered defense: how mucus and tight junctions seal the intestinal barrier

The colonic mucosa provides a vital defensive barrier separating the body from the microbial populations residing in the intestinal lumen. Indeed, growing evidence shows that loss of this barrier may cause disease or exacerbate disease progression. The loss of barrier integrity increases the translo...

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Veröffentlicht in:Journal of molecular medicine (Berlin, Germany) Germany), 2017-09, Vol.95 (9), p.927-934
Hauptverfasser: Capaldo, Christopher T., Powell, Domonica N., Kalman, Daniel
Format: Artikel
Sprache:eng
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Zusammenfassung:The colonic mucosa provides a vital defensive barrier separating the body from the microbial populations residing in the intestinal lumen. Indeed, growing evidence shows that loss of this barrier may cause disease or exacerbate disease progression. The loss of barrier integrity increases the translocation of bacterial antigens and stimulates inflammation in the intestinal mucosa, which is the central pathological feature of inflammatory bowel diseases (IBDs). This review focuses on how intestinal mucus and intercellular tight junctions (TJs) act together to maintain the integrity of the colonic barrier and how barrier integrity is dysregulated in IBD.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-017-1557-x