Frequency‐Swept Integrated Solid Effect

The efficiency of continuous wave dynamic nuclear polarization (DNP) experiments decreases at the high magnetic fields used in contemporary high‐resolution NMR applications. To recover the expected signal enhancements from DNP, we explored time domain experiments such as NOVEL which matches the electron Rabi frequency to the nuclear Larmor frequency to mediate polarization transfer. However, satisfying this matching condition at high frequencies is technically demanding. As an alternative we report here frequency‐swept integrated solid effect (FS‐ISE) experiments that allow low power sweeps of the exciting microwave frequencies to constructively integrate the negative and positive polarizations of the solid effect, thereby producing a polarization efficiency comparable to (±10 % difference) NOVEL. Finally, the microwave frequency modulation results in field profiles that exhibit new features that we coin the “stretched” solid effect. Expanding the repertoire: Frequency‐swept integrated solid effect (FS‐ISE) is introduced as a strategy for time domain dynamic nuclear polarization (DNP). In contrast to the original implementation of the ISE that employs sweeps of B0, the new pulse sequence is suitable for high‐resolution NMR applications.