Microbiota Disruption Induced by Early Use of Broad Spectrum Antibiotics is an Independent Risk Factor of Outcome after Allogeneic Stem Cell Transplantation

Highlights • Intestinal microbiota play an important role in patients with allogeneic SCT • Early use of antibiotics affects intestinal microbiota composition • Early use of antibiotics influences the outcome of allogeneic SCT recipients

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Veröffentlicht in:	Biology of blood and marrow transplantation 2017-05, Vol.23 (5), p.845-852
Hauptverfasser:	Weber, Daniela, Jenq, Robert R, Peled, Jonathan U, Taur, Ying, Hiergeist, Andreas, Koestler, Josef, Dettmer, Katja, Weber, Markus, Wolff, Daniel, Hahn, Joachim, Pamer, Eric G, Herr, Wolfgang, Gessner, André, Oefner, Peter J, van den Brink, Marcel R.M, Holler, Ernst
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute intestinal GVHD Adult Allogeneic stem cell transplantation Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacology Clostridium - drug effects Female Gastrointestinal Microbiome - drug effects Graft vs Host Disease - etiology Graft vs Host Disease - mortality Hematology, Oncology and Palliative Medicine Humans Infections - etiology Infections - mortality Intestinal microbiome Male Outcome Retrospective Studies Risk Factors Stem Cell Transplantation - adverse effects Stem Cell Transplantation - methods Stem Cell Transplantation - mortality Survival Analysis Time-to-Treatment Transplantation, Homologous Treatment Outcome Treatment with broad-spectrum antibiotics Young Adult
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Beschreibung
Zusammenfassung:	Highlights • Intestinal microbiota play an important role in patients with allogeneic SCT • Early use of antibiotics affects intestinal microbiota composition • Early use of antibiotics influences the outcome of allogeneic SCT recipients
ISSN:	1083-8791 1523-6536
DOI:	10.1016/j.bbmt.2017.02.006