Telocytes - a Hope for Cardiac Repair after Myocardial Infarction

Cardiovascular diseases, particularly myocardial infarction, remain the leading cause of morbidity and mortality worldwide, even though pharmacological and interventional therapies improved significantly in the last years. Moreover, despite encouraging results of cell - based therapies in experiment...

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Veröffentlicht in:Mædica 2016-12, Vol.11 (4), p.325-329
Hauptverfasser: Galrinho, Ruxandra Dragoi, Manole, Catalin Gabriel, Vinereanu, Dragos
Format: Artikel
Sprache:eng
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Zusammenfassung:Cardiovascular diseases, particularly myocardial infarction, remain the leading cause of morbidity and mortality worldwide, even though pharmacological and interventional therapies improved significantly in the last years. Moreover, despite encouraging results of cell - based therapies in experimental myocardial infarction models, clinical trials showed inconsistent and modest efficiency. Therefore the next step should be the revealing of a new cell type, capable of regenerating the damaged myocardium. Telocytes (TCs), a relatively new type of interstitial cells, were described few years ago and are credited with important roles in regenerative therapies. In this paper we review their most important characteristics and functions, showing the evidences of their potential role in cardiac repair and regeneration. Our research leads to the conclusion that TCs might be a novel target for therapeutic strategies in myocardial infarction.
ISSN:1841-9038
2069-6116