APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review
Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently observed in colorectal cancer (CRC). The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the signifi...
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| Veröffentlicht in: | Oncotarget 2017-07, Vol.8 (28), p.46468-46479 |
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| creator | Liang, Tie-Jun Wang, Hong-Xu Zheng, Yan-Yan Cao, Ying-Qing Wu, Xiaoyu Zhou, Xin Dong, Shu-Xiao |
| description | Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently observed in colorectal cancer (CRC). The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the significance of APC methylation in CRC. The study included a total of 24 articles and 2025 CRC patients. The frequency of APC promoter hypermethylation was significantly higher in colorectal adenoma than in normal colorectal tissue, OR was 5.76, 95% CI, 2.45-13.56; p |
| doi_str_mv | 10.18632/oncotarget.17576 |
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The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the significance of APC methylation in CRC. The study included a total of 24 articles and 2025 CRC patients. The frequency of APC promoter hypermethylation was significantly higher in colorectal adenoma than in normal colorectal tissue, OR was 5.76, 95% CI, 2.45-13.56; p<0.0001, I2=0%. APC promoter more frequently hypermethylated in CRC stage I compared to normal colorectal tissue, OR was 13.42, 95% CI, 3.66-49.20; p<0.0001, I2=31%. The risk of incidence of CRC was significantly correlated to APC promoter hypermethylation, pooled OR was 9.80, 95%CI, 6.07-15.81; p<0.00001, I2=43%. APC methylation was not associated with grade, stage of CRC as well as tumor location, patients' gender, and smoking behavior. The results indicate that APC promoter hypermethylation is an early event in carcinogenesis of CRC, could be a valuable diagnostic marker for early-stage CRC. APC methylation is not significantly associated with overall survival in patients with CRC. APC is a potential drug target for development of personalized treatment.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.17576</identifier><identifier>PMID: 28515349</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Adenomatous Polyposis Coli Protein - genetics ; Biomarkers, Tumor ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - genetics ; DNA Methylation ; Early Detection of Cancer ; Epigenesis, Genetic ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Meta-Analysis ; Neoplasm Grading ; Neoplasm Staging ; Odds Ratio ; Promoter Regions, Genetic ; Publication Bias ; Sex Factors</subject><ispartof>Oncotarget, 2017-07, Vol.8 (28), p.46468-46479</ispartof><rights>Copyright: © 2017 Liang et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-17e8cb55611db68ea8abdb54c0c55ff8357f8ee3e33ca976447a696d327e3b493</citedby><cites>FETCH-LOGICAL-c422t-17e8cb55611db68ea8abdb54c0c55ff8357f8ee3e33ca976447a696d327e3b493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542282/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542282/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28515349$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Tie-Jun</creatorcontrib><creatorcontrib>Wang, Hong-Xu</creatorcontrib><creatorcontrib>Zheng, Yan-Yan</creatorcontrib><creatorcontrib>Cao, Ying-Qing</creatorcontrib><creatorcontrib>Wu, Xiaoyu</creatorcontrib><creatorcontrib>Zhou, Xin</creatorcontrib><creatorcontrib>Dong, Shu-Xiao</creatorcontrib><title>APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently observed in colorectal cancer (CRC). The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the significance of APC methylation in CRC. The study included a total of 24 articles and 2025 CRC patients. The frequency of APC promoter hypermethylation was significantly higher in colorectal adenoma than in normal colorectal tissue, OR was 5.76, 95% CI, 2.45-13.56; p<0.0001, I2=0%. APC promoter more frequently hypermethylated in CRC stage I compared to normal colorectal tissue, OR was 13.42, 95% CI, 3.66-49.20; p<0.0001, I2=31%. The risk of incidence of CRC was significantly correlated to APC promoter hypermethylation, pooled OR was 9.80, 95%CI, 6.07-15.81; p<0.00001, I2=43%. APC methylation was not associated with grade, stage of CRC as well as tumor location, patients' gender, and smoking behavior. The results indicate that APC promoter hypermethylation is an early event in carcinogenesis of CRC, could be a valuable diagnostic marker for early-stage CRC. APC methylation is not significantly associated with overall survival in patients with CRC. APC is a potential drug target for development of personalized treatment.</description><subject>Adenomatous Polyposis Coli Protein - genetics</subject><subject>Biomarkers, Tumor</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - genetics</subject><subject>DNA Methylation</subject><subject>Early Detection of Cancer</subject><subject>Epigenesis, Genetic</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Meta-Analysis</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Staging</subject><subject>Odds Ratio</subject><subject>Promoter Regions, Genetic</subject><subject>Publication Bias</subject><subject>Sex Factors</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU9P4zAQxS3EChDLB-CCfOSSEsdxYnNAQhULSEjsYfdsTZxJa-TaxXZB-fabpfwpc5mR5r03I_0IOWXljMmGVxfBm5AhLjDPWCvaZo8cMVWrohKC7-_Mh-QkpadyKlG3slIH5LCSggleqyPSX_-e0-W4xrjCvBwdZBs8HUKkCNGNtLew8CHZRMNATXAhosngqAFvMF5SoJMPCvDgxv8q8D11NmOEvIlII75YfP1JfgzgEp6892Py99fNn_ld8fB4ez-_fihMXVW5YC1K0wnRMNZ3jUSQ0PWdqE1phBgGyUU7SESOnBtQbVPXLTSq6XnVIu9qxY_J1TZ3velW2Bv0OYLT62hXEEcdwOrvG2-XehFetBDTA7KaAs7fA2J43mDKemWTQefAY9gkzVRZMqaYLCcp20pNDClFHD7PsFK_AdJfgPQboMlztvvfp-MDB_8HL6mR3Q</recordid><startdate>20170711</startdate><enddate>20170711</enddate><creator>Liang, Tie-Jun</creator><creator>Wang, Hong-Xu</creator><creator>Zheng, Yan-Yan</creator><creator>Cao, Ying-Qing</creator><creator>Wu, Xiaoyu</creator><creator>Zhou, Xin</creator><creator>Dong, Shu-Xiao</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170711</creationdate><title>APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review</title><author>Liang, Tie-Jun ; Wang, Hong-Xu ; Zheng, Yan-Yan ; Cao, Ying-Qing ; Wu, Xiaoyu ; Zhou, Xin ; Dong, Shu-Xiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-17e8cb55611db68ea8abdb54c0c55ff8357f8ee3e33ca976447a696d327e3b493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenomatous Polyposis Coli Protein - genetics</topic><topic>Biomarkers, Tumor</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - genetics</topic><topic>DNA Methylation</topic><topic>Early Detection of Cancer</topic><topic>Epigenesis, Genetic</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Male</topic><topic>Meta-Analysis</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Staging</topic><topic>Odds Ratio</topic><topic>Promoter Regions, Genetic</topic><topic>Publication Bias</topic><topic>Sex Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Liang, Tie-Jun</creatorcontrib><creatorcontrib>Wang, Hong-Xu</creatorcontrib><creatorcontrib>Zheng, Yan-Yan</creatorcontrib><creatorcontrib>Cao, Ying-Qing</creatorcontrib><creatorcontrib>Wu, Xiaoyu</creatorcontrib><creatorcontrib>Zhou, Xin</creatorcontrib><creatorcontrib>Dong, Shu-Xiao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Tie-Jun</au><au>Wang, Hong-Xu</au><au>Zheng, Yan-Yan</au><au>Cao, Ying-Qing</au><au>Wu, Xiaoyu</au><au>Zhou, Xin</au><au>Dong, Shu-Xiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-07-11</date><risdate>2017</risdate><volume>8</volume><issue>28</issue><spage>46468</spage><epage>46479</epage><pages>46468-46479</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>Adenomatous polyposis coli (APC) promoter hypermethylation has been frequently observed in colorectal cancer (CRC). The association between APC promoter methylation and clinicopathological significance in CRC is under investigation. We performed a meta-analysis to quantitatively evaluate the significance of APC methylation in CRC. The study included a total of 24 articles and 2025 CRC patients. The frequency of APC promoter hypermethylation was significantly higher in colorectal adenoma than in normal colorectal tissue, OR was 5.76, 95% CI, 2.45-13.56; p<0.0001, I2=0%. APC promoter more frequently hypermethylated in CRC stage I compared to normal colorectal tissue, OR was 13.42, 95% CI, 3.66-49.20; p<0.0001, I2=31%. The risk of incidence of CRC was significantly correlated to APC promoter hypermethylation, pooled OR was 9.80, 95%CI, 6.07-15.81; p<0.00001, I2=43%. APC methylation was not associated with grade, stage of CRC as well as tumor location, patients' gender, and smoking behavior. The results indicate that APC promoter hypermethylation is an early event in carcinogenesis of CRC, could be a valuable diagnostic marker for early-stage CRC. APC methylation is not significantly associated with overall survival in patients with CRC. APC is a potential drug target for development of personalized treatment.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>28515349</pmid><doi>10.18632/oncotarget.17576</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenomatous Polyposis Coli Protein - genetics Biomarkers, Tumor Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics DNA Methylation Early Detection of Cancer Epigenesis, Genetic Female Genetic Association Studies Genetic Predisposition to Disease Humans Male Meta-Analysis Neoplasm Grading Neoplasm Staging Odds Ratio Promoter Regions, Genetic Publication Bias Sex Factors |
| title | APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review |
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